PM2.5 exposure during pregnancy is associated with altered placental expression of lipid metabolic genes in a US birth cohort

• Published in: Environmental research Vol. 211; p. 113066
• Main Authors: Kaur, Kirtan, Lesseur, Corina, Deyssenroth, Maya A., Kloog, Itai, Schwartz, Joel D., Marsit, Carmen J., Chen, Jia
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.08.2022
• Subjects: Air pollution; biochemical pathways; breathing; cell communication; child health; fetal development; gene expression; gene expression regulation; gene ontology; glucose; inflammation; lipids; males; Metabolism; Placenta; PM2.5; postnatal development; Pregnancy; regression analysis; remote sensing; Rhode Island; sequence analysis; Sex differences; Rhode Island; Pregnancy; Air pollution; Sex differences; Placenta; Metabolism; PM2.5

Inhalation of ambient PM2.5, shown to be able to cross the placenta, has been linked to adverse obstetric and postnatal metabolic health outcomes. The placenta regulates fetal growth and influences postnatal development via fetal programming. Placental gene expression may be influenced by intrauteri...