Arsenic methylation, GSTO1 polymorphisms, and metabolic syndrome in an arseniasis endemic area of southwestern Taiwan

• Published in: Chemosphere (Oxford) Vol. 88; no. 4; pp. 432 - 438
• Main Authors: Chen, Jein-Wen, Wang, Shu-Li, Wang, Ya-Hui, Sun, Chien-Wen, Huang, Yeou-Lih, Chen, Chien-Jen, Li, Wan-Fen
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.07.2012; Elsevier
• Subjects: acids; Adult; alleles; Animal, plant and microbial ecology; Applied ecology; Arsenic; Arsenic - metabolism; Arsenic Poisoning; Arsenic Poisoning - complications; Arsenic Poisoning - epidemiology; Arsenic Poisoning - genetics; Arsenic Poisoning - metabolism; Asian Continental Ancestry Group - genetics; Asian People; Biological and medical sciences; cacodylic acid; complications; Ecotoxicology, biological effects of pollution; Endemic Diseases; epidemiology; Female; Fundamental and applied biological sciences. Psychology; General aspects; Genes; genetic polymorphism; Genetic Predisposition to Disease; Genetic Predisposition to Disease - genetics; Genetics; Glutathione Transferase; Glutathione Transferase - genetics; hairs; Humans; Logistic Models; Male; Metabolic syndrome; Metabolic Syndrome - complications; metabolism; Methylation; Methyltransferases; Methyltransferases - genetics; Middle Aged; noninsulin-dependent diabetes mellitus; odds ratio; Polymethyl methacrylates; Polymorphism; Polymorphism, Genetic; Risk; Risk factor; Taiwan; Taiwan - epidemiology; Type 2 diabetes mellitus; Villages; Asia; Taiwan; Type 2 diabetes mellitus; Arsenic; Metabolic syndrome; Methylation; Risk factor; Trace element; Endemic species; Syndrome; Polymorphism

► MetS in relation to arsenic methylation was examined in a cohort with previous high exposure. ► Subjects with MetS experienced higher inorganic arsenic ingestion. ► Decreasing MMA ratio was associated with an increased risk for MetS. ► The increased risk for MetS was further modified by the GSTO1...