Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells - Li, Jing-qiu; Wu, Xian; Gan, Lu; Yang, Xiang-liang; Miao, Ze-hong (Acta pharmacologica Sinica, 2017)
Keywords: 5-Fluorouracil; Antineoplastic drugs; Antitumor agents; Apoptosis; Biomedical and Life Sciences; Biomedicine; Cancer; Cisplatin; Clinical trials; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA damage; DNA repair; Drug development; Drug resistance; Gemcitabine; Hepatocellular carcinoma; Hepatoma; Hypoxia; Immunology; Internal Medicine; Liver cancer; Medical Microbiology; Membrane potential; Mitochondria; Original; original-article; Pharmacology/Toxicology; Thioguanine; Thymidylate synthase; Vaccine; 5-fluorouracil; hypoxia; drug resistance; sorafenib; hepatocellular carcinoma