Azadirachtin Attenuates Carcinogen Benzo(a) Pyrene-Induced DNA Damage, Cell Cycle Arrest, Apoptosis, Inflammatory, Metabolic, and Oxidative Stress in HepG2 Cells

• Published in: Antioxidants Vol. 12; no. 11; p. 2001
• Main Authors: John, Annie, Raza, Haider
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.11.2023
• Subjects: Antioxidants; Antitumor agents; Apoptosis; Azadirachtin; Benzo(a)pyrene; Bioenergetics; Cancer; Carcinogens; Care and treatment; Cell culture; Cell cycle; Cell growth; Cigarette smoke; Cigarettes; Cytochrome; Cytotoxicity; DNA; DNA damage; Enzymes; Ethylenediaminetetraacetic acid; Flow cytometry; Glutathione; HepG2 cells; Homeostasis; Inflammation; Kinases; Lipid peroxidation; Liver; Medical research; Metabolic activation; Metabolic rate; Metabolism; Neem; Oncology, Experimental; Oxidants; Oxidative stress; Peptides; Polyphenols; Proteins; Pyrene; Reactive oxygen species; Smoking; Toxicity; United Kingdom; United Kingdom > UK; United States > US

Azadirachtin (AZD), a limonoid from the versatile, tropical neem tree (Azadirachta indica), is well known for its many medicinal, and pharmacological effects. Its effects as an anti-oxidant, anti-inflammatory, and anti-cancer agent are well known. However, not many studies have explored the effects...