Influences of renal function descriptors on population pharmacokinetic modeling of vancomycin in Chinese adult patients

• Published in: Acta pharmacologica Sinica Vol. 39; no. 2; pp. 286 - 293
• Main Authors: Ji, Xi-wei, Ji, Shuang-min, He, Xiao-rong, Zhu, Xiao, Chen, Rong, Lu, Wei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2018; Nature Publishing Group
• Subjects: Adult; Age; Aged; Aged, 80 and over; Antibiotics; Asian Continental Ancestry Group; Bayes Theorem; Bayesian analysis; Biomedicine; China; Computer simulation; Creatinine; Excretion; Female; Glomerular Filtration Rate; Humans; Immunology; Influence coefficient; Internal Medicine; Kidney - metabolism; Male; Mathematical models; Medical Microbiology; Metabolic Clearance Rate; Middle Aged; Models, Biological; Original; original-article; Pharmacokinetics; Pharmacology/Toxicology; Population; Renal function; Vaccine; Vancomycin; Vancomycin - administration & dosage; Vancomycin - blood; Vancomycin - pharmacokinetics; 万古霉素;描述符;成年;中国;人口;模特儿;肾;模型确认; creatinine; Chinese adult patients; vancomycin; renal function; glomerular filtration rate (GFR); population pharmacokinetics; NONMEM

Vancomycin, a glycopeptide antibiotic for the treatment of grampositive infections, is mainly eliminated via glomerular filtration. Thus, its therapeutic effects are affected predominantly by renal function. The aim of this study was to develop a population pharmacokinetic model of vancomycin for Ch...