Distribution and intensity of constraint in mammalian genomic sequence

• Published in: Genome research Vol. 15; no. 7; pp. 901 - 913
• Main Authors: Cooper, Gregory M., Stone, Eric A., Asimenos, George, Green, Eric D., Batzoglou, Serafim, Sidow, Arend
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.07.2005
• Subjects: Animals; Base Sequence; Computational Biology - methods; Conserved Sequence; Cystic Fibrosis Transmembrane Conductance Regulator; Evolution, Molecular; Gene Components; Gene Expression Profiling - methods; Genome; Humans; Interspersed Repetitive Sequences; Mammals - genetics; Molecular Sequence Data; Sensitivity and Specificity; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid

Comparisons of orthologous genomic DNA sequences can be used to characterize regions that have been subject to purifying selection and are enriched for functional elements. We here present the results of such an analysis on an alignment of sequences from 29 mammalian species. The alignment captures...