Induction of EAE by T cells specific for alpha B-crystallin depends on prior viral infection in the CNS

• Published in: International immunology Vol. 19; no. 3; pp. 277 - 285
• Main Authors: Verbeek, Richard, van Dongen, Henrike, Wawrousek, Eric F., Amor, Sandra, van Noort, Johannes M.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.03.2007; Oxford Publishing Limited (England)
• Subjects: Adoptive Transfer; alpha B-crystallin; alpha-Crystallin B Chain - genetics; alpha-Crystallin B Chain - immunology; alpha-Crystallin B Chain - metabolism; Alphavirus Infections - complications; Alphavirus Infections - immunology; Alphavirus Infections - virology; Animals; Cells, Cultured; Central Nervous System Viral Diseases - complications; Central Nervous System Viral Diseases - immunology; Central Nervous System Viral Diseases - virology; EAE; Encephalomyelitis, Autoimmune, Experimental - immunology; Encephalomyelitis, Autoimmune, Experimental - virology; Immune Tolerance; Inflammation Mediators - immunology; Lymphocyte Activation; Mice; Mice, Biozzi; Mice, Inbred C57BL; Mice, Knockout; Pathogens; Semliki Forest virus; SFV; Spinal Cord - immunology; T cells; T-Lymphocytes - immunology; T-Lymphocytes - transplantation; Time Factors; EAE; SFV; T cells; alpha B-crystallin; MS

While myelin-reactive T cells are widely believed to play a pathogenic role in multiple sclerosis (MS), no substantial differences appear to exist in T-cell responses to myelin antigens between MS patients and healthy subjects. As an example, indistinguishable peripheral T-cell responses and serum a...