Echinacea purpurea up-regulates CYP1A2, CYP3A4 and MDR1 gene expression by activation of pregnane X receptor pathway
Abstract 1. This study investigated the mechanism underlying Echinacea-mediated induction of CYP1A2, CYP3A4 and MDR1 in terms of human pregnane X receptor (PXR) activation. 2. Crude extracts and fractions of Echinacea purpurea were tested for PXR activation in HepG2 cells by a reporter gene assay. Q...
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Published in | Xenobiotica Vol. 45; no. 3; pp. 218 - 229 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Informa UK Ltd
01.03.2015
Informa Healthcare |
Subjects | |
Online Access | Get full text |
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