Association of anger-related traits with SNPs in the TPH gene

• Published in: Molecular psychiatry Vol. 7; no. 9; pp. 1023 - 1029
• Main Authors: Rujescu, D, Giegling, I, Bondy, B, Gietl, A, Zill, P, Möller, H-J
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.01.2002
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Aggression; Aggressiveness; Anger; Anger - physiology; Biological and medical sciences; Emotions; Enzymes; Female; Gene Frequency; Gene polymorphism; Genetic diversity; Genotype; Genotype & phenotype; Germany; Humans; Hypotheses; Male; Medical genetics; Medical sciences; Mental and behavioral disorders; Middle Aged; Multivariate Analysis; Neurosciences; Personality; Personality traits; Polymorphism; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Questionnaires; Serotonin; Serotonin - metabolism; Single-nucleotide polymorphism; Suicide; Suicide, Attempted; Tryptophan; Tryptophan hydroxylase; Tryptophan Hydroxylase - genetics; Tryptophan Hydroxylase - metabolism; Germany; Anger; Human; Impulse control disorder; Healthy subject; Enzyme; Pathogenesis; Volunteer; Suicide attempt; Behavioral disorder; Case study; Gene; Tryptophan 5-monooxygenase; Serotoninergic pathway; Genetics; Oxidoreductases; Single nucleotide polymorphism

Since both aggression-related traits and serotonergic activity are partially heritable and correlate inversely, variations in genes of the serotonergic system might then, to some extent, account for variations in aggression-related behavior. Tryptophan hydroxylase (TPH) is the rate limiting biosynth...