HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity

• Published in: Nature cell biology Vol. 21; no. 8; pp. 1027 - 1040
• Main Authors: Wu, Shiying, Zhang, Qian, Zhang, Fei, Meng, Fansen, Liu, Shengduo, Zhou, Ruyuan, Wu, Qingzhe, Li, Xinran, Shen, Li, Huang, Jun, Qin, Jun, Ouyang, Songying, Xia, Zongping, Song, Hai, Feng, Xin-Hua, Zou, Jian, Xu, Pinglong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2019; Nature Publishing Group
• Subjects: 13/1; 13/2; 13/21; 13/51; 13/89; 13/95; 14/19; 38/77; 631/67; 631/67/395; 631/80/509; 631/80/86; 64/116; 64/60; 82/47; 82/58; 82/83; AKT1 protein; Antiviral drugs; Apoptosis; Biomedical and Life Sciences; Cancer Research; Carcinogenesis; Cell Biology; Cell research; Cytokines; Damage; Deoxyribonucleic acid; Developmental Biology; DNA; Epidermal growth factor receptors; ErbB protein; ErbB-2 protein; Genetic aspects; Health aspects; Host-Pathogen Interactions; Humans; Immune response; Immunity; Immunity, Innate - immunology; Immunoregulation; Kinases; Life Sciences; Membrane proteins; Membrane Proteins - immunology; Membrane Proteins - metabolism; Microorganisms; Negative feedback; Phosphorylation; Physiological aspects; Protein kinases; Protein-tyrosine kinase receptors; Proto-Oncogene Proteins c-akt - immunology; Proto-Oncogene Proteins c-akt - metabolism; Receptor, ErbB-2 - immunology; Receptor, ErbB-2 - metabolism; Senescence; Signal transduction; Signaling; Stem Cells; Surveillance; Tumorigenesis; Tyrosine; Ubiquitination; Ubiquitination - immunology; China

Sensing cytosolic DNA through the cGAS–STING pathway constitutes a widespread innate immune mechanism to monitor cellular damage and microbial invasion. Evading this surveillance is crucial in tumorigenesis, but the process remains largely unexplored. Here, we show that the receptor tyrosine kinase...