TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma - Liu, Jieqiong; Liao, Shan; Diop-Frimpong, Benjamin; Chen, Wei; Goel, Shom; Naxerova, Kamila; Ancukiewicz, Marek; Boucher, Yves; Jain, Rakesh K.; Xu, Lei (Proceedings of the National Academy of Sciences - PNAS, 2012)
Keywords: animal models; Animals; Antibiotics, Antineoplastic - administration & dosage; Antibiotics, Antineoplastic - pharmacokinetics; Antibodies, Neutralizing - administration & dosage; Antibodies, Neutralizing - immunology; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Antineoplastics; Apoptosis; Apoptosis - drug effects; Biological Sciences; Blood vessels; Blotting, Western; breast neoplasms; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer; Cell growth; Cell Line, Tumor; Cell Proliferation - drug effects; collagen; Collagen Type I - metabolism; Collagens; Doxorubicin - pharmacokinetics; Doxorubicin - therapeutic use; drug therapy; drugs; Female; gene overexpression; Humans; Lung Neoplasms - metabolism; Lung Neoplasms - prevention & control; Lung Neoplasms - secondary; Metastasis; Mice; Mice, Nude; neoplasm cells; neutralizing antibodies; Perfusion; Physical Sciences; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Receptors; Receptors, Transforming Growth Factor beta - genetics; Receptors, Transforming Growth Factor beta - metabolism; Signal Transduction - drug effects; Signal Transduction - genetics; Tissue Distribution; transforming growth factor beta; Transforming Growth Factor beta - antagonists & inhibitors; Transforming Growth Factor beta - immunology; Transforming Growth Factor beta - metabolism; Treatment Outcome; Tumor Burden - drug effects; Tumors; Xenograft Model Antitumor Assays