MTNR1A and MTNR1B Gene Variants of the Melatonin Receptor and Arterial Stiffness in Persons without Arterial Hypertension

• Published in: Bulletin of experimental biology and medicine Vol. 174; no. 4; pp. 460 - 463
• Main Authors: Kolomeichuk, S. N., Korneva, V. A., Kuznetsova, T. Yu, Korostovtseva, L. S., Bochkarev, M. V., Sviryaev, Yu.V., Blagonravov, M. L.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2023; Springer; Springer Nature B.V
• Subjects: Alleles; Antioxidants; Biomedical and Life Sciences; Biomedicine; Blood; Blood Glucose - analysis; Blood tests; Body mass index; Cardiovascular disease; Cardiovascular system; Cell Biology; Cholesterol; Comparative analysis; Fibrin; Fibrinogen; Genes; Genetics; Genotype & phenotype; Genotyping; Glucose; Homozygotes; Humans; Hypertension; Internal Medicine; Laboratories; Laboratory Medicine; Low density lipoprotein; Low density lipoproteins; Medical examination; Medical research; Medicine, Experimental; Melatonin; MTNR1B gene; Pathology; Polymorphism, Single Nucleotide - genetics; Receptor, Melatonin, MT1 - genetics; Receptor, Melatonin, MT2 - genetics; Triglycerides; Vascular Stiffness - genetics; arterial stiffness; 24-h BP monitoring; polymorphism; melatonin; melatonin receptors

A comparative analysis of vascular stiffness indices and the results of blood test was carried out in 85 healthy donors aged 19-64 years, carriers of polymorphic variants of type 1 and type 2 melatonin receptor genes. The associations of polymorphic markers of type 1 MTNR1A ( rs34532313 ) and type 2...