The machinery of macroautophagy

• Published in: Cell research Vol. 24; no. 1; pp. 24 - 41
• Main Authors: Feng, Yuchen, He, Ding, Yao, Zhiyuan, Klionsky, Daniel J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2014; Nature Publishing Group
• Subjects: 631/80/39/2346; Animals; Autophagy - physiology; Biomedical and Life Sciences; Cell Biology; Homeostasis; Humans; Life Sciences; Lysosomes - metabolism; Mammals; Membranes; Nutrients; Phagosomes - metabolism; Pichia - cytology; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Proteins; Review; Saccharomyces cerevisiae - cytology; Saccharomyces cerevisiae - metabolism; Vacuoles; Yeasts; 分子生物学; 哺乳动物细胞; 机器; 真核细胞; 神经退行性疾病; 自噬作用; 调节机制; 降解途径; stress; autophagy; vacuole; degradation; autophagosome; lysosome; phagophore
• ISSN: 1001-0602; 1748-7838; 1748-7838
• DOI: 10.1038/cr.2013.168

Autophagy is a primarily degradative pathway that takes place in all eukaryotic cells. It is used for recycling cytoplasm to generate macromolecular building blocks and energy under stress conditions, to remove superfluous and damaged organelles to adapt to changing nutrient conditions and to mainta...