Loss of protein kinase C delta alters mammary gland development and apoptosis

• Published in: Cell death & disease Vol. 1; no. 1; p. e17
• Main Authors: Allen-Petersen, B L, Miller, M R, Neville, M C, Anderson, S M, Nakayama, K I, Reyland, M E
• Format: Journal Article
• Language: English
• Published: England Springer Nature B.V 01.01.2010; Nature Publishing Group
• Subjects: Animals; Apoptosis; Caspase 3 - metabolism; Cells, Cultured; Dexamethasone - pharmacology; Female; Mammary Glands, Animal - cytology; Mammary Glands, Animal - growth & development; Mammary Glands, Animal - metabolism; Mice; Mice, Knockout; Original; Protein Kinase C-delta - genetics; Protein Kinase C-delta - metabolism; Protein Kinase C-delta - physiology; Thymus Gland - metabolism; Thymus Gland - radiation effects

As apoptotic pathways are commonly deregulated in breast cancer, exploring how mammary gland cell death is regulated is critical for understanding human disease. We show that primary mammary epithelial cells from protein kinase C delta (PKCδ) -/- mice have a suppressed response to apoptotic agents i...