Asymmetric inheritance of spindle microtubule-organizing centres preserves replicative lifespan

• Published in: Nature cell biology Vol. 21; no. 8; pp. 952 - 965
• Main Authors: Manzano-López, Javier, Matellán, Laura, Álvarez-Llamas, Alejandra, Blanco-Mira, José Carlos, Monje-Casas, Fernando
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2019; Nature Publishing Group
• Subjects: 14/1; 14/19; 14/35; 14/63; 631/136/7; 631/80/470/2284; 631/80/641/1656; 631/80/642/333; 82/29; 82/80; Aging; Biomedical and Life Sciences; Brewer's yeast; Cancer Research; Cell Biology; Cell division; Cell research; Cells; Developmental Biology; Differential distribution; Extrachromosomal inheritance; Fruit flies; Life Sciences; Life span; Localization; Microtubules; Mitochondria; Mitochondrial inheritance; Physiological aspects; Saccharomyces cerevisiae; Stem Cells; Yeast; Spain

The differential distribution of the microtubule-organizing centres (MTOCs) that orchestrate spindle formation during cell division is a fascinating phenomenon originally described in Saccharomyces cerevisiae and later found to be conserved during stem cell divisions in organisms ranging from Drosop...