Epstein-Barr viral product-containing exosomes promote fibrosis and nasopharyngeal carcinoma progression through activation of YAP1/FAPα signaling in fibroblasts

• Published in: Journal of experimental & clinical cancer research Vol. 41; no. 1; pp. 1 - 23
• Main Authors: Lee, Po-Ju, Sui, Yun-Hua, Liu, Tzu-Tung, Tsang, Ngan-Ming, Huang, Chen-Han, Lin, Ting-Yi, Chang, Kai-Ping, Liu, Shu-Chen
• Format: Journal Article
• Language: English
• Published: London BioMed Central 20.08.2022; BMC
• Subjects: Biopsy; Cancer; Collagen; Cytokines; EBV; Epstein-Barr virus; Exosome; Experiments; Fibroblast; Fibroblasts; Laboratory animals; Metastasis; MicroRNAs; Nasopharyngeal carcinoma; NPC; Proteins; Throat cancer; Vascular endothelial growth factor; Taiwan

Background The progression of nasopharyngeal carcinoma (NPC) is profoundly affected by Epstein-Barr virus (EBV) infection. However, the role of EBV in the intercommunication between NPC and surrounding stromal cells has yet to be explored. Methods NPC biopsies were obtained for immunohistochemical (...