Effective Infection with Dengue Virus in Experimental Neonate and Adult Mice through the Intranasal Route
Dengue virus, the causative agent of dengue fever, life-threatening hemorrhagic fever, and shock syndrome, is mainly transmitted to humans through mosquito vectors. It can also be transmitted through atypical routes, including needle stick injury, vertical transmission, blood transfusion, and organ...
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Published in | Viruses Vol. 14; no. 7; p. 1394 |
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Abstract | Dengue virus, the causative agent of dengue fever, life-threatening hemorrhagic fever, and shock syndrome, is mainly transmitted to humans through mosquito vectors. It can also be transmitted through atypical routes, including needle stick injury, vertical transmission, blood transfusion, and organ transplantation. In addition, sporadic cases which have no clear infectious causes have raised the respiratory exposure concerns, and the risks remain unclear. Here, we analyze the respiratory infectivity of the dengue virus in BALB/c suckling and adult immunodeficient mice by the intranasal inoculation of dengue virus serotype 2. The infected mice presented with clinical symptoms, including excitement, emaciation, malaise, and death. Viremia was detected for 3 days post inoculation. Histopathological changes were observed in the brain, liver, and spleen. The virus showed evident brain tropism post inoculation and viral loads peaked at 7 days post inoculation. Furthermore, the virus was isolated from the infected mice; the sequence homology between the origin and isolates was 99.99%. Similar results were observed in adult IFN-α/β receptor-deficient mice. Overall, dengue virus can infect suckling mice and adult immune-deficient mice via the nasal route. This study broadens our perception of atypical dengue transmission routes and provides evidence of nasal transmission of dengue virus in the absence of mosquito vectors. |
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AbstractList | Dengue virus, the causative agent of dengue fever, life-threatening hemorrhagic fever, and shock syndrome, is mainly transmitted to humans through mosquito vectors. It can also be transmitted through atypical routes, including needle stick injury, vertical transmission, blood transfusion, and organ transplantation. In addition, sporadic cases which have no clear infectious causes have raised the respiratory exposure concerns, and the risks remain unclear. Here, we analyze the respiratory infectivity of the dengue virus in BALB/c suckling and adult immunodeficient mice by the intranasal inoculation of dengue virus serotype 2. The infected mice presented with clinical symptoms, including excitement, emaciation, malaise, and death. Viremia was detected for 3 days post inoculation. Histopathological changes were observed in the brain, liver, and spleen. The virus showed evident brain tropism post inoculation and viral loads peaked at 7 days post inoculation. Furthermore, the virus was isolated from the infected mice; the sequence homology between the origin and isolates was 99.99%. Similar results were observed in adult IFN-α/β receptor-deficient mice. Overall, dengue virus can infect suckling mice and adult immune-deficient mice via the nasal route. This study broadens our perception of atypical dengue transmission routes and provides evidence of nasal transmission of dengue virus in the absence of mosquito vectors. |
Audience | Academic |
Author | Hua, Dong Zhang, Junjie Wang, Yalan Ding, Xiaoyan Zhou, Xiaoyang Qiu, Minyue Liu, Minchi Li, Jintao Yan, Huacheng Zhao, Lixin Zeng, Jie |
AuthorAffiliation | 1 Department of Biosafety, School of Basic Medicine, Army Medical University, Chongqing 400038, China; 18810467206@163.com (M.Q.); lxzhao98@163.com (L.Z.); zhangjj59@mail2.sysu.edu.cn (J.Z.); 2019010636@ybu.edu.cn (Y.W.); 15520085274@163.com (M.L.); 13919454081@163.com (D.H.); dxywork2012@sina.cn (X.D.); 15123188321@126.com (X.Z.); zengjie2019@yeah.net (J.Z.) 2 Institute of Immunology, People’s Liberate Army, Army Medical University, Chongqing 400038, China 3 Center for Disease Control and Prevention of Southern Military Theatre, Guangzhou 510507, China; watshing@126.com |
AuthorAffiliation_xml | – name: 3 Center for Disease Control and Prevention of Southern Military Theatre, Guangzhou 510507, China; watshing@126.com – name: 1 Department of Biosafety, School of Basic Medicine, Army Medical University, Chongqing 400038, China; 18810467206@163.com (M.Q.); lxzhao98@163.com (L.Z.); zhangjj59@mail2.sysu.edu.cn (J.Z.); 2019010636@ybu.edu.cn (Y.W.); 15520085274@163.com (M.L.); 13919454081@163.com (D.H.); dxywork2012@sina.cn (X.D.); 15123188321@126.com (X.Z.); zengjie2019@yeah.net (J.Z.) – name: 2 Institute of Immunology, People’s Liberate Army, Army Medical University, Chongqing 400038, China |
Author_xml | – sequence: 1 fullname: Qiu, Minyue – sequence: 2 fullname: Zhao, Lixin – sequence: 3 fullname: Zhang, Junjie – sequence: 4 fullname: Wang, Yalan – sequence: 5 fullname: Liu, Minchi – sequence: 6 fullname: Hua, Dong – sequence: 7 fullname: Ding, Xiaoyan – sequence: 8 fullname: Zhou, Xiaoyang – sequence: 9 fullname: Zeng, Jie – sequence: 10 fullname: Yan, Huacheng – sequence: 11 fullname: Li, Jintao |
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Cites_doi | 10.1371/journal.pntd.0006198 10.1016/S0255-0857(21)02174-5 10.1080/21505594.2022.2060464 10.3389/fcimb.2017.00336 10.1038/s41467-017-01923-4 10.1371/journal.pntd.0009024 10.7554/eLife.47458 10.1016/j.coviro.2020.10.004 10.1371/journal.pntd.0001760 10.1002/lt.23755 10.1093/jtm/taz087 10.1093/clinids/18.2.248 10.1016/S0140-6736(14)60572-9 10.3390/v11010087 10.1128/CMR.11.3.480 10.4269/ajtmh.2010.09-0552 10.1016/j.virusres.2007.03.003 10.1016/j.jcv.2014.08.021 10.1053/j.seminhematol.2006.09.016 10.1111/ajt.15270 10.1086/423807 10.1016/S0166-3542(98)00063-1 10.1016/j.virol.2008.11.047 10.1038/s41564-019-0476-8 10.3201/eid1010.031037 10.1016/S0140-6736(08)60158-0 10.4269/ajtmh.1952.1.30 10.1371/journal.pntd.0001324 10.1016/j.tins.2015.08.003 10.1128/JCM.00209-07 10.1186/1423-0127-20-65 10.1099/vir.0.045088-0 10.1002/kjm2.12271 10.1371/journal.pntd.0005520 10.1128/JVI.01568-07 10.1080/23744235.2018.1521004 10.1086/591699 10.1038/s41598-017-04839-7 |
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References | Arragain (ref_8) 2017; 6 Gubler (ref_36) 1998; 11 Thaithumyanon (ref_7) 1994; 18 Korhonen (ref_20) 2014; 61 ref_13 ref_35 Menon (ref_38) 2019; 19 Lee (ref_23) 2020; 36 Lee (ref_27) 2007; 126 Deng (ref_12) 2017; 8 Blackley (ref_29) 2007; 81 Chen (ref_37) 2004; 39 Gregory (ref_17) 2010; 82 Aaron (ref_16) 2008; 47 ref_18 Lee (ref_33) 2019; 51 ref_39 Feng (ref_32) 2022; 13 Paul (ref_30) 2017; 7 Chow (ref_40) 2015; 38 Guzman (ref_3) 2015; 385 Saigal (ref_10) 2013; 19 Messina (ref_1) 2019; 4 Sabin (ref_25) 1952; 1 Nir (ref_14) 1965; 46 Brady (ref_2) 2019; 8 Rather (ref_42) 2017; 7 Hirsch (ref_5) 1990; 141 Liew (ref_34) 2020; 27 Gupta (ref_11) 2008; 371 ref_21 Orozco (ref_24) 2012; 93 Tavakoli (ref_19) 2007; 45 Porzia (ref_28) 2018; 32 Malavige (ref_41) 2007; 25 Azmawati (ref_43) 2013; 42 Lee (ref_22) 2013; 20 Hiscott (ref_26) 2020; 43 Alter (ref_9) 2007; 44 Wagner (ref_6) 2004; 10 Verma (ref_31) 2009; 385 ref_4 Brooks (ref_15) 1999; 41 |
References_xml | – ident: ref_21 doi: 10.1371/journal.pntd.0006198 – volume: 25 start-page: 143 year: 2007 ident: ref_41 article-title: Dengue viral infections as a cause of encephalopathy publication-title: Indian J. Med. Microbiol. doi: 10.1016/S0255-0857(21)02174-5 contributor: fullname: Malavige – volume: 6 start-page: 324 year: 2017 ident: ref_8 article-title: Vertical transmission of dengue virus in the peripartum period and viral kinetics in newborns and breast milk: New data publication-title: J. Pediatr. Infect. Dis. Soc. contributor: fullname: Arragain – volume: 46 start-page: 443 year: 1965 ident: ref_14 article-title: West Nile Virus infection in mice following exposure to a viral aerosol publication-title: Br. J. Exp. Pathol. contributor: fullname: Nir – volume: 141 start-page: 629 year: 1990 ident: ref_5 article-title: Metropolitan transmission of dengue by accidental inoculation at a hospital publication-title: Ann. Med. Intern. contributor: fullname: Hirsch – volume: 13 start-page: 670 year: 2022 ident: ref_32 article-title: Glycosylation of viral proteins: Implication in virus-host interaction and virulence publication-title: Virulence doi: 10.1080/21505594.2022.2060464 contributor: fullname: Feng – volume: 7 start-page: 336 year: 2017 ident: ref_42 article-title: Prevention and control strategies to counter dengue virus infection publication-title: Front. Cell Infect. Microbiol. doi: 10.3389/fcimb.2017.00336 contributor: fullname: Rather – volume: 8 start-page: 1648 year: 2017 ident: ref_12 article-title: Intranasal infection and contact transmission of Zika virus in guinea pigs publication-title: Nat. Commun. doi: 10.1038/s41467-017-01923-4 contributor: fullname: Deng – ident: ref_35 doi: 10.1371/journal.pntd.0009024 – volume: 8 start-page: e47458 year: 2019 ident: ref_2 article-title: Mapping the emerging burden of dengue publication-title: eLife doi: 10.7554/eLife.47458 contributor: fullname: Brady – volume: 43 start-page: iii year: 2020 ident: ref_26 article-title: Editorial overview: The challenge to defeat dengue publication-title: Curr. Opin. Virol. doi: 10.1016/j.coviro.2020.10.004 contributor: fullname: Hiscott – ident: ref_4 doi: 10.1371/journal.pntd.0001760 – volume: 19 start-page: 1413 year: 2013 ident: ref_10 article-title: Transmission of dengue virus from a donor to a recipient after living donor liver transplantation publication-title: Liver Transpl. doi: 10.1002/lt.23755 contributor: fullname: Saigal – volume: 27 start-page: taz087 year: 2020 ident: ref_34 article-title: The first case of sexual transmission of dengue in Spain publication-title: J. Travel Med. doi: 10.1093/jtm/taz087 contributor: fullname: Liew – volume: 18 start-page: 248 year: 1994 ident: ref_7 article-title: Dengue infection complicated by severe hemorrhage and vertical transmission in a parturient woman publication-title: Clin. Infect. Dis. doi: 10.1093/clinids/18.2.248 contributor: fullname: Thaithumyanon – volume: 385 start-page: 453 year: 2015 ident: ref_3 article-title: Dengue publication-title: Lancet doi: 10.1016/S0140-6736(14)60572-9 contributor: fullname: Guzman – volume: 42 start-page: 538 year: 2013 ident: ref_43 article-title: Evaluation of communication for behavioral impact (COMBI) program in dengue prevention: A qualitative and quantitative study in Selangor, Malaysia publication-title: Iran J. Public Health contributor: fullname: Azmawati – ident: ref_13 doi: 10.3390/v11010087 – volume: 11 start-page: 480 year: 1998 ident: ref_36 article-title: Dengue and dengue hemorrhagic fever publication-title: Clin. Microbiol. Rev. doi: 10.1128/CMR.11.3.480 contributor: fullname: Gubler – volume: 82 start-page: 922 year: 2010 ident: ref_17 article-title: Clinical and laboratory features that differentiate dengue from other febrile illnesses in an endemic area—Puerto Rico, 2007–2008 publication-title: Am. J. Trop. Med. Hyg. doi: 10.4269/ajtmh.2010.09-0552 contributor: fullname: Gregory – volume: 126 start-page: 216 year: 2007 ident: ref_27 article-title: Dengue viruses can infect human primary lung epithelia as well as lung carcinoma cells, and can also induce the secretion of IL-6 and RANTES publication-title: Virus Res. doi: 10.1016/j.virusres.2007.03.003 contributor: fullname: Lee – volume: 61 start-page: 353 year: 2014 ident: ref_20 article-title: Approach to non-invasive sampling in dengue diagnostics: Exploring virus and NS1 antigen detection in saliva and urine of travelers with dengue publication-title: J. Clin. Virol. doi: 10.1016/j.jcv.2014.08.021 contributor: fullname: Korhonen – volume: 32 start-page: 3 year: 2018 ident: ref_28 article-title: Human nasal immune system: A special site for immune response establishment publication-title: J. Biol. Regul. Homeost. contributor: fullname: Porzia – volume: 44 start-page: 32 year: 2007 ident: ref_9 article-title: Emerging infectious diseases that threaten the blood supply publication-title: Semin. Hematol. doi: 10.1053/j.seminhematol.2006.09.016 contributor: fullname: Alter – volume: 19 start-page: 1838 year: 2019 ident: ref_38 article-title: Dengue virus transmission from live donor liver graft publication-title: Am. J. Transpl. doi: 10.1111/ajt.15270 contributor: fullname: Menon – volume: 39 start-page: e56 year: 2004 ident: ref_37 article-title: Transmission of dengue virus without a mosquito vector: Nosocomial mucocutaneous transmission and other routes of transmission publication-title: Clin. Infect. Dis. doi: 10.1086/423807 contributor: fullname: Chen – volume: 41 start-page: 57 year: 1999 ident: ref_15 article-title: Interferon-alpha protects mice against lethal infection with St Louis encephalitis virus delivered by the aerosol and subcutaneous routes publication-title: Antivir. Res. doi: 10.1016/S0166-3542(98)00063-1 contributor: fullname: Brooks – volume: 385 start-page: 425 year: 2009 ident: ref_31 article-title: West Nile virus infection modulates human brain microvascular endothelial cells tight junction proteins and cell adhesion molecules: Transmigration across the in vitro blood–brain barrier publication-title: Virology doi: 10.1016/j.virol.2008.11.047 contributor: fullname: Verma – volume: 4 start-page: 1508 year: 2019 ident: ref_1 article-title: The current and future global distribution and population at risk of dengue publication-title: Nat. Microbiol. doi: 10.1038/s41564-019-0476-8 contributor: fullname: Messina – volume: 10 start-page: 1872 year: 2004 ident: ref_6 article-title: Nosocomial acquisition of dengue publication-title: Emerg. Infect. Dis. doi: 10.3201/eid1010.031037 contributor: fullname: Wagner – volume: 371 start-page: 299 year: 2008 ident: ref_11 article-title: Nosocomial dengue in health-care workers publication-title: Lancet doi: 10.1016/S0140-6736(08)60158-0 contributor: fullname: Gupta – volume: 1 start-page: 30 year: 1952 ident: ref_25 article-title: Research on dengue during World War II publication-title: Am. J. Trop. Med. Hyg. doi: 10.4269/ajtmh.1952.1.30 contributor: fullname: Sabin – ident: ref_39 doi: 10.1371/journal.pntd.0001324 – volume: 38 start-page: 598 year: 2015 ident: ref_40 article-title: The molecular constituents of the blood–brain barrier publication-title: Trends Neurosci. doi: 10.1016/j.tins.2015.08.003 contributor: fullname: Chow – volume: 45 start-page: 1523 year: 2007 ident: ref_19 article-title: Identification of dengue virus in respiratory specimens from a patient who had recently traveled from a region where dengue virus infection is endemic publication-title: J. Clin. Microbiol. doi: 10.1128/JCM.00209-07 contributor: fullname: Tavakoli – volume: 20 start-page: 65 year: 2013 ident: ref_22 article-title: Dengue virus infection induces autophagy: An in vivo study publication-title: J. Biomed. Sci. doi: 10.1186/1423-0127-20-65 contributor: fullname: Lee – volume: 93 start-page: 2152 year: 2012 ident: ref_24 article-title: Characterization of a model of lethal dengue virus 2 infection in C57BL/6 mice deficient in the alpha/beta interferon receptor publication-title: J. Gen. Virol. doi: 10.1099/vir.0.045088-0 contributor: fullname: Orozco – volume: 36 start-page: 911 year: 2020 ident: ref_23 article-title: Regulation of autophagy, glucose uptake, and glycolysis under dengue virus infection publication-title: Kaohsiung J. Med. Sci. doi: 10.1002/kjm2.12271 contributor: fullname: Lee – ident: ref_18 doi: 10.1371/journal.pntd.0005520 – volume: 81 start-page: 13325 year: 2007 ident: ref_29 article-title: Primary human splenic macrophages, but not T or B cells, are the principal target cells for dengue virus infection in vitro publication-title: J. Virol. doi: 10.1128/JVI.01568-07 contributor: fullname: Blackley – volume: 51 start-page: 150 year: 2019 ident: ref_33 article-title: Probable female to male sexual transmission of dengue virus infection publication-title: Infect. Dis. doi: 10.1080/23744235.2018.1521004 contributor: fullname: Lee – volume: 47 start-page: 931 year: 2008 ident: ref_16 article-title: Intranasal transmission of hepatitis C virus: Virological and clinical evidence publication-title: Clin. Infect. Dis. doi: 10.1086/591699 contributor: fullname: Aaron – volume: 7 start-page: 4722 year: 2017 ident: ref_30 article-title: Osteopontin facilitates West Nile virus neuroinvasion via neutrophil “Trojan horse” transport publication-title: Sci. Rep. doi: 10.1038/s41598-017-04839-7 contributor: fullname: Paul |
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SubjectTerms | A6 mice Blood transfusion Brain Care and treatment Control Dengue fever Dengue hemorrhagic fever dengue virus Dengue viruses DENV-2 Diagnosis Encephalitis Epidemics Genomes Hemorrhagic fever Homology Identification and classification Immunodeficiency Infections Infectivity Inoculation intranasal route Laboratory animals neonate mice Patient outcomes Spleen Suckling behavior Transplantation Transplantation of organs, tissues, etc Tropism Vectors Viremia Viruses West Nile virus α-Interferon |
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Title | Effective Infection with Dengue Virus in Experimental Neonate and Adult Mice through the Intranasal Route |
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