Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation

• Published in: Stem cells and development Vol. 15; no. 3; p. 407
• Main Authors: Barkho, Basam Z, Song, Hongjun, Aimone, James B, Smrt, Richard D, Kuwabara, Tomoko, Nakashima, Kinichi, Gage, Fred H, Zhao, Xinyu
• Format: Journal Article
• Language: English
• Published: United States 01.06.2006
• Subjects: Animals; Animals, Newborn; Astrocytes - cytology; Astrocytes - metabolism; Basic Helix-Loop-Helix Transcription Factors - genetics; Cell Differentiation - drug effects; Cells, Cultured; Cytokines - pharmacology; Gene Expression Profiling; Gene Expression Regulation - drug effects; Humans; Mice; Nerve Tissue Proteins - genetics; Neurons - cytology; Neurons - drug effects; Promoter Regions, Genetic - drug effects; Proteins - metabolism; Rats; Stem Cells - cytology; Stem Cells - drug effects

Multipotent neural stem/progenitor cells (NSPCs) can be isolated from many regions of the adult central nervous system (CNS), yet neurogenesis is restricted to the hippocampus and subventricular zone in vivo. Identification of the molecular cues that modulate NSPC fate choice is a prerequisite for t...