Immortalized Hepatocytes Using Human Artificial Chromosome

• Published in: Cell transplantation Vol. 17; no. 1-2; pp. 165 - 171
• Main Authors: Ito, Masahiro, Ito, Ryoutaro, Yoshihara, Daisuke, Ikeno, Masashi, Kamiya, Megumi, Suzuki, Nobutaka, Horiguchi, Akihiko, Nagata, Hideo, Yamamoto, Toshiyuki, Kobayashi, Naoya, Fox, Ira J., Okazaki, Tsuneko, Miyakama, Syuichi
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2008; SAGE Publishing
• Subjects: Actins - metabolism; Albumins - metabolism; alpha 1-Antitrypsin - metabolism; Aminoacyltransferases - metabolism; Animals; Antigens, Polyomavirus Transforming - genetics; Cell Transformation, Viral; CHO Cells; Chromosomes, Artificial, Human; Cricetinae; Cricetulus; Dipeptidyl Peptidase 4 - metabolism; Glucose-6-Phosphatase - metabolism; Hepatocytes - metabolism; Hepatocytes - pathology; Hepatocytes - transplantation; Liver Diseases - therapy; Male; Rats; Simian virus 40 - immunology; SV40; Human artificial minichromosome; Hepatocyte transplantation

The shortage of organ donors has impeded the development of human hepatocyte transplantation. Immortalized hepatocytes could provide an unlimited supply of transplantable cells. To determine whether immortalized hepatocytes could provide global metabolic support in end-stage liver disease, rat hepat...