Preparation of a mimetic and degradable poly(ethylene glycol) by a non-eutectic mixture of organocatalysts (NEMO) via a one-pot two-step process

• Published in: RSC advances Vol. 9; no. 68; pp. 40013 - 40016
• Main Authors: Moins, S., Loyer, P., Odent, J., Coulembier, O.
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 04.12.2019; The Royal Society of Chemistry
• Subjects: Butyrolactone; Chemistry; condensation reactions; green chemistry; lactones; Life Sciences; Micelles; Organic chemistry; organocatalysts; Polyethylene glycol; Two step method; Eutectic mixture; Gamma butyrolactone; Catalysts; Mixtures; Functionalizations; Two-step process; Eutectics; Organocatalysts; Green chemistry; One pot; Polyethylene glycols

A one-pot, two-step method for the preparation of degradable PEG is here presented. The full process addresses the requirements imposed by green chemistry and involves the use of a single and nontoxic non-eutectic mixture of organocatalysts. The strategy relies on the polycondensation of PEG800 afte...