The Wnt/β-catenin and PI3K/Akt signaling pathways promote EMT in gastric cancer by epigenetic regulation via H3 lysine 27 acetylation - Song, Yue; Li, Zhao-xia; Liu, Xi; Wang, Rui; Li, Li-wei; Zhang, Qingyu (Tumor biology, 2017)
Keywords: 1-Phosphatidylinositol 3-kinase; Acetylation; AKT protein; Authorship; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - biosynthesis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics; beta Catenin - antagonists & inhibitors; beta Catenin - genetics; Cancer therapies; Cell Line, Tumor; Chemotherapy; Chromatin; Chromones - administration & dosage; Deoxyribonucleic acid; DNA; DNA methylation; Enzyme inhibitors; Epigenesis, Genetic; Epigenetics; Epithelial-Mesenchymal Transition - genetics; Female; Gastric cancer; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Glycogen; Glycogen synthase kinase 3; Glycogen Synthase Kinase 3 beta - biosynthesis; Glycogen Synthase Kinase 3 beta - genetics; Histone H3; Humans; Immunohistochemistry; Immunoprecipitation; Kinases; Lysine; Lysine - genetics; Male; Mesenchyme; Metastasis; Morpholines - administration & dosage; Phosphatidylinositol 3-Kinases - antagonists & inhibitors; Phosphatidylinositol 3-Kinases - genetics; Phosphorylation; Polymerase chain reaction; Protein Processing, Post-Translational - genetics; Proteins; Proto-Oncogene Proteins c-akt - genetics; Signal transduction; Stomach Neoplasms - genetics; Stomach Neoplasms - pathology; Sulfonamides - administration & dosage; Transcription Factor 4; Transcription Factors - biosynthesis; Transcription Factors - genetics; Tumorigenesis; Tumors; Western blotting; Wnt protein; Wnt Signaling Pathway - genetics; β-Catenin; China; PI3K/Akt pathway; Wnt/β-catenin pathway; histone modification; twist