Ganoderma Lucidum Triterpenoids Improve Maternal Separation-Induced Anxiety- and Depression-like Behaviors in Mice by Mitigating Inflammation in the Periphery and Brain

• Published in: Nutrients Vol. 14; no. 11; p. 2268
• Main Authors: Mi, Xue, Zeng, Gui-Rong, Liu, Jie-Qing, Luo, Zhou-Song, Zhang, Ling, Dai, Xiao-Man, Fang, Wen-Ting, Zhang, Jing, Chen, Xiao-Chun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.05.2022; MDPI
• Subjects: Adults; Alzheimer's disease; Antifungal agents; Anxiety; Behavior; Care and treatment; Chemical properties; Child abuse & neglect; Females; Health aspects; Inflammation; Laboratory animals; Males; Mental depression; Mental illness; Physiological aspects; Psychic trauma in children; Reishi; Risk factors; Stress; Terpenes; China; maternal separation; inflammatory response; anxiety; depression; Ganoderma lucidum triterpenoids

Although early life stress (ELS) can increase susceptibility to adulthood psychiatric disorders and produce a greater inflammatory response in a stressful event, targeted preventive and therapeutic drugs still remain scarce. Ganoderma lucidum triterpenoids (GLTs) can exert anti-inflammatory effects...