Genomic regions exhibiting positive selection identified from dense genotype data

• Published in: Genome research Vol. 15; no. 11; pp. 1553 - 1565
• Main Authors: Carlson, Christopher S., Thomas, Daryl J., Eberle, Michael A., Swanson, Johanna E., Livingston, Robert J., Rieder, Mark J., Nickerson, Deborah A.
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.11.2005
• Subjects: Asian - genetics; Base Sequence; Black or African American - genetics; DNA Primers; Evolution, Molecular; Gene Frequency; Genes - genetics; Genome, Human - genetics; Genomics - methods; Genotype; Humans; Letters; Molecular Sequence Data; Polymorphism, Genetic; Selection, Genetic; Sequence Analysis, DNA; White People - genetics

The allele frequency spectrum of polymorphisms in DNA sequences can be used to test for signatures of natural selection that depart from the expected frequency spectrum under the neutral theory. We observed a significant ( P = 0.001) correlation between the Tajima's D test statistic in full res...