Multi-omics integration reveals a six-malignant cell maker gene signature for predicting prognosis in high-risk neuroblastoma

• Published in: Frontiers in neuroinformatics Vol. 16; p. 1034793
• Main Authors: Yan, Zijun, Liu, Qiming, Cao, Ziyang, Wang, Jinxia, Zhang, Hongyang, Liu, Jiangbin, Zou, Lin
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 10.11.2022; Frontiers Media S.A
• Subjects: Algorithms; Cell cycle; Children; DNA methylation; Gene expression; Genes; high-risk neuroblastoma; Inflammation; malignant cell maker gene; Medical prognosis; Metabolism; Microenvironments; multi-omics integration; Mutation; Neuroblastoma; Neuroscience; Patients; Prognosis; prognostic model; Receptor activity modifying proteins; Regression analysis; Risk groups; single-cell; Solid tumors; Sympathetic nervous system

Background: Neuroblastoma is the most common extracranial solid tumor of childhood, arising from the sympathetic nervous system. High-risk neuroblastoma (HRNB) remains a major therapeutic challenge with low survival rates despite the intensification of therapy. This study aimed to develop a malignan...