LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes

• Published in: Molecular cancer Vol. 19; no. 1; pp. 1 - 24
• Main Authors: Zhou, Cefan, Yi, Changhua, Yi, Yongxiang, Qin, Wenying, Yan, Yanan, Dong, Xueying, Zhang, Xuewen, Huang, Yuan, Zhang, Rui, Wei, Jie, Ali, Declan William, Michalak, Marek, Chen, Xing-Zhen, Tang, Jingfeng
• Format: Journal Article
• Language: English
• Published: London BioMed Central 29.07.2020; BMC
• Subjects: Autophagy; Cancer therapies; Carcinogenesis; Chemoresistance; Chemotherapy; Cloning; Confocal microscopy; Deoxyribonucleic acid; DNA; Gemcitabine; Gemcitabine resistance; Genes; Kinases; LEF protein; Medical prognosis; miR-619-5p; mRNA; Pancreatic cancer; Phagocytosis; Polymerase chain reaction; Proteins; PVT1; Roles; Signal transduction; Transmission electron microscopy; Tumor cell lines; Tumors; Western blotting; Wnt protein; Wnt/β-catenin; Xenografts; β-Catenin; China

Background Pancreatic cancer is one of the most lethal malignancies and has an extremely poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major challenge. The long noncoding RNA PVT1 was reported to be involved in carcinogenesis and chemoresistance; however, the...