Functional Interaction between Responses to Lactic Acidosis and Hypoxia Regulates Genomic Transcriptional Outputs

• Published in: Cancer research (Chicago, Ill.) Vol. 72; no. 2; pp. 491 - 502
• Main Authors: XIAOHU TANG, LUCAS, Joseph E, CHEN, Julia Ling-Yu, LAMONTE, Gregory, JIANLI WU, CHANGSHENG WANG, Michael, KOUMENIS, Constantinos, CHI, Jen-Tsan
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.01.2012
• Subjects: Acidity; Acidosis, Lactic - genetics; Acidosis, Lactic - metabolism; Activating Transcription Factor 4 - genetics; Activating Transcription Factor 4 - metabolism; Amino acids; Antineoplastic agents; Biological and medical sciences; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Cancer; Cell Hypoxia - genetics; Cell Line, Tumor; Cell survival; copy number; Data processing; DNA; Female; Gene Amplification; Gene expression; Gene Expression Regulation, Neoplastic; Genomics; Humans; Hypoxia-inducible factor 1 alpha; Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors; Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis; Inflammation; Lactic acidosis; Medical sciences; Microenvironments; Oxygen; Pharmacology. Drug treatments; Protein folding; Signal Transduction; Solid tumors; Transcription; Transfection; Tumor cells; Tumor Microenvironment; Tumors; Metabolic disorder; Oxygen; Transcription; Genomics; Interaction; Genetics; Hypoxia; Acid base balance disorder; Lactic acid; Acidosis; Genome

Within solid tumor microenvironments, lactic acidosis, and hypoxia each have powerful effects on cancer pathophysiology. However, the influence that these processes exert on each other is unknown. Here, we report that a significant portion of the transcriptional response to hypoxia elicited in cance...