Apolipoprotein M/sphingosine 1-phosphate protects against diabetic nephropathy

• Published in: Translational research : the journal of laboratory and clinical medicine Vol. 258; pp. 16 - 34
• Main Authors: Kurano, Makoto, Tsukamoto, Kazuhisa, Shimizu, Tomo, Hara, Masumi, Yatomi, Yutaka
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2023
• Subjects: Animals; Apolipoprotein M; Apolipoproteins - genetics; Apolipoproteins - metabolism; Apolipoproteins - pharmacology; Apolipoproteins M - genetics; Apolipoproteins M - metabolism; Diabetes Mellitus; Diabetic Nephropathies - prevention & control; Diabetic nephropathy; Mice; Mitochondria; SIRT1; Sphingosine; Sphingosine 1-phosphate; PAS; S1P2; HFD; S1P3; VPC; GFP mice; Apolipoprotein M; Sphingosine 1-phosphate; ApoM-knockdown mice; CM-ApoM; GFP; HDL; SD; Mitochondria; ApoM; S1P; ANOVA; LDL; STZ; Diabetic nephropathy; ApoM-KO mice; HbA1c; BMI; eGFR; PBS; siCtl; ApoM mice; KO; WT mice; CM-Null; SIRT1; N.S; TCA; Cre; S1P1; JTE; TEM; ELISA

Diabetic nephropathy remains a common cause of end-stage renal failure and its associated mortality around the world. Sphingosine 1-phosphate (S1P) is a multifunctional lipid mediator and binds to HDL via apolipoprotein M (ApoM). Since HDL has been reported to be epidemiologically associated with ki...