New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway

• Published in: Acta pharmacologica Sinica Vol. 36; no. 9; pp. 1074 - 1084
• Main Authors: Chen, Kang, Chu, Bi-zhu, Liu, Feng, Li, Bin, Gao, Chun-mei, Li, Lu-lu, Sun, Qin-sheng, Shen, Zhi-fa, Jiang, Yu-yang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2015; Nature Publishing Group
• Subjects: Acridines - chemistry; Acridines - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Apoptosis; Benzimidazoles - chemistry; Benzimidazoles - pharmacology; Biomedical and Life Sciences; Biomedicine; Caspases - metabolism; Cell Line, Tumor; Colon - drug effects; Colon - metabolism; Colon - pathology; Colonic Neoplasms - drug therapy; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; HCT116 Cells; Humans; Immunology; Internal Medicine; JNK Mitogen-Activated Protein Kinases - metabolism; Medical Microbiology; Original; original-article; Pharmacology/Toxicology; Reactive Oxygen Species - metabolism; Signal Transduction - drug effects; Vaccine; 体外培养; 体外诱导; 信号通路; 吖啶; 细胞凋亡; 结肠癌; 苯并咪唑; 衍生物; anticancer drug; benzimidazole acridine; colon cancer; ROS; death receptor-5; JNK1; apoptosis

Aim： To investigate the mechanisms underlying anticancer action of the benzimidazole acridine derivative N-{（1H-benzo[d]imidazol-2-yl） methyl}-2-butylacridin-9-amine （8m） against human colon cancer cells in vitro. Methods： Human colon cancer cell lines SW480 and HCT116 were incubated in the presence...