New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway - Chen, Kang; Chu, Bi-zhu; Liu, Feng; Li, Bin; Gao, Chun-mei; Li, Lu-lu; Sun, Qin-sheng; Shen, Zhi-fa; Jiang, Yu-yang (Acta pharmacologica Sinica, 2015)
Keywords: Acridines - chemistry; Acridines - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Apoptosis; Benzimidazoles - chemistry; Benzimidazoles - pharmacology; Biomedical and Life Sciences; Biomedicine; Caspases - metabolism; Cell Line, Tumor; Colon - drug effects; Colon - metabolism; Colon - pathology; Colonic Neoplasms - drug therapy; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; HCT116 Cells; Humans; Immunology; Internal Medicine; JNK Mitogen-Activated Protein Kinases - metabolism; Medical Microbiology; Original; original-article; Pharmacology/Toxicology; Reactive Oxygen Species - metabolism; Signal Transduction - drug effects; Vaccine; 体外培养; 体外诱导; 信号通路; 吖啶; 细胞凋亡; 结肠癌; 苯并咪唑; 衍生物; anticancer drug; benzimidazole acridine; colon cancer; ROS; death receptor-5; JNK1; apoptosis