Oxidized alginate hydrogels with the GHK peptide enhance cord blood mesenchymal stem cell osteogenesis: A paradigm for metabolomics-based evaluation of biomaterial design

• Published in: Acta biomaterialia Vol. 88; pp. 224 - 240
• Main Authors: Klontzas, Michail E., Reakasame, Supachai, Silva, Raquel, Morais, Jose C.F., Vernardis, Spyros, MacFarlane, Robert J., Heliotis, Manolis, Tsiridis, Eleftherios, Panoskaltsis, Nicki, Boccaccini, Aldo R., Mantalaris, Athanasios
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2019; Elsevier BV
• Subjects: Alginates; Alginic acid; Alkaline phosphatase; Biocompatibility; Biodegradability; Biodegradation; Biomaterials; Biomedical materials; Bioprocessing; Blood; Bone matrix; Cell Differentiation; Cell fate; Cell Proliferation; Cord blood; Crosslinking; Differentiation (biology); Extracellular matrix; Extracellular Matrix - chemistry; Fetal Blood - cytology; Fetal Blood - metabolism; Gelatin; Gene expression; GHK; Glycine; Heterogeneity; Histidine; Humans; Hydrogels; Hydrogels - chemistry; Lysine; Materials Testing; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; Mesenchyme; Metabolism; Metabolome; Metabolomics; Osteoblastogenesis; Osteoblasts; Osteogenesis; Osteogenic differentiation; Peptides; Peptides - chemistry; Stem cells; Umbilical cord; Metabolomics; GHK; Hydrogels; Metabolism; Osteogenic differentiation; Mesenchymal stem cells

[Display omitted] Oxidized alginate hydrogels are appealing alternatives to natural alginate due to their favourable biodegradability profiles and capacity to self-crosslink with amine containing molecules facilitating functionalization with extracellular matrix cues, which enable modulation of stem...