β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression

• Published in: Journal of neuroinflammation Vol. 19; no. 1; pp. 1 - 21
• Main Authors: Liu, Yang, Song, Nanshan, Yao, Hang, Jiang, Siyuan, Wang, Yueping, Zheng, Ying, Zhou, Yuanzhang, Ding, Jianhua, Hu, Gang, Lu, Ming
• Format: Journal Article
• Language: English
• Published: London BioMed Central 01.10.2022; BMC
• Subjects: Agonists; Animal models; Animals; Antidepressants; Astrocytes; Behavior; Cell viability; cGAS–STING; Corticosterone; Cytokines; Cytoplasm; Depression; Dopamine; Dopamine D2 receptors; Dopamine receptors; Drd2 agonist; Drug development; Flow cytometry; Hippocampus; Homeostasis; Immunofluorescence; Inflammation; Interleukin 6; Mass spectroscopy; Mental depression; Pathophysiology; Phenotypes; Proteins; Serotonin; Signal transduction; Social interactions; Social research; Stat3 protein; Therapeutic targets; Tumor necrosis factor-TNF; UNC9995; β-Arrestin2

Background Major depressive disorder (MDD) is a prevalent and devastating psychiatric illness. Unfortunately, the current therapeutic practice, generally depending on the serotonergic system for drug treatment is unsatisfactory and shows intractable side effects. Multiple evidence suggests that dopa...