β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression - Liu, Yang; Song, Nanshan; Yao, Hang; Jiang, Siyuan; Wang, Yueping; Zheng, Ying; Zhou, Yuanzhang; Ding, Jianhua; Hu, Gang; Lu, Ming (Journal of neuroinflammation, 2022)
Keywords: Agonists; Animal models; Animals; Antidepressants; Astrocytes; Behavior; Cell viability; cGAS–STING; Corticosterone; Cytokines; Cytoplasm; Depression; Dopamine; Dopamine D2 receptors; Dopamine receptors; Drd2 agonist; Drug development; Flow cytometry; Hippocampus; Homeostasis; Immunofluorescence; Inflammation; Interleukin 6; Mass spectroscopy; Mental depression; Pathophysiology; Phenotypes; Proteins; Serotonin; Signal transduction; Social interactions; Social research; Stat3 protein; Therapeutic targets; Tumor necrosis factor-TNF; UNC9995; β-Arrestin2