Understanding the genetics of viral drug resistance by integrating clinical data and mining of the scientific literature

• Published in: Scientific reports Vol. 12; no. 1; p. 14476
• Main Authors: Goto, An, Rodriguez-Esteban, Raul, Scharf, Sebastian H, Morris, Garrett M
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 25.08.2022; Nature Publishing Group UK; Nature Portfolio
• Subjects: Disulfide bonds; Drug development; Drug resistance; Genetics; Genotypes; Health risks; Hepatitis B; Mutation; Phenotypes; Public health; Severe acute respiratory syndrome coronavirus 2; Viral diseases

Abstract Drug resistance caused by mutations is a public health threat for existing and emerging viral diseases. A wealth of evidence about these mutations and their clinically associated phenotypes is scattered across the literature, but a comprehensive perspective is usually lacking. This work aim...