Comparative Characterization of Human and Equine Mesenchymal Stromal Cells: A Basis for Translational Studies in the Equine Model

• Published in: Cell transplantation Vol. 25; no. 1; pp. 109 - 124
• Main Authors: Hillmann, Aline, Ahrberg, Annette B., Brehm, Walter, Heller, Sandra, Josten, Christoph, Paebst, Felicitas, Burk, Janina
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2016; Sage Publications Ltd; SAGE Publishing
• Subjects: Adult; Animals; Biomarkers - metabolism; CD105 antigen; CD14 antigen; CD29 antigen; CD34 antigen; CD44 antigen; CD45 antigen; CD73 antigen; CD90 antigen; Cell Differentiation; Cell Lineage; Cell Movement; Cell Proliferation; Collagen; Decorin; Female; Histocompatibility antigen HLA; Horses; Humans; Immunophenotyping; Joint diseases; Male; Mesenchymal stem cells; Mesenchymal Stromal Cells - cytology; Mesenchyme; Middle Aged; Models, Animal; Orthopedics; Real-Time Polymerase Chain Reaction; Stromal cells; Tenascin; Tenascin C; Tendons - metabolism; Translation; Translational Medical Research; Young Adult; Animal model; Mesenchymal stromal cells (MSCs); Adipose; Cell therapy; Horse; Tendon

Multipotent mesenchymal stromal cells (MSCs) have gained tremendous attention as potential therapeutic agents for the treatment of orthopedic diseases. Promising results have been obtained after application of MSCs for treatment of tendon and joint disease in the equine model, making it appear favor...