Leukotrienes: Underappreciated Mediators of Innate Immune Responses

• Published in: The Journal of immunology (1950) Vol. 174; no. 2; pp. 589 - 594
• Main Authors: Peters-Golden, Marc, Canetti, Claudio, Mancuso, Peter, Coffey, Michael J
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.01.2005
• Subjects: Animals; Human immunodeficiency virus; Humans; Immunity, Innate - immunology; Inflammation Mediators - physiology; Leukotrienes - biosynthesis; Leukotrienes - deficiency; Leukotrienes - physiology

Leukotrienes are bronchoconstrictor and vasoactive lipid mediators that are targets in the treatment of asthma. Although they are increasingly recognized to exert broad proinflammatory effects, their role in innate immune responses is less well appreciated. These molecules are indeed synthesized by...