Leukotrienes: Underappreciated Mediators of Innate Immune Responses

Leukotrienes are bronchoconstrictor and vasoactive lipid mediators that are targets in the treatment of asthma. Although they are increasingly recognized to exert broad proinflammatory effects, their role in innate immune responses is less well appreciated. These molecules are indeed synthesized by...

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Bibliographic Details
Published inThe Journal of immunology (1950) Vol. 174; no. 2; pp. 589 - 594
Main Authors Peters-Golden, Marc, Canetti, Claudio, Mancuso, Peter, Coffey, Michael J
Format Journal Article
LanguageEnglish
Published United States Am Assoc Immnol 15.01.2005
Subjects
Animals
Human immunodeficiency virus
Humans
Immunity, Innate - immunology
Inflammation Mediators - physiology
Leukotrienes - biosynthesis
Leukotrienes - deficiency
Leukotrienes - physiology
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Summary:Leukotrienes are bronchoconstrictor and vasoactive lipid mediators that are targets in the treatment of asthma. Although they are increasingly recognized to exert broad proinflammatory effects, their role in innate immune responses is less well appreciated. These molecules are indeed synthesized by resident and recruited leukocytes during infection. Acting via cell surface G protein-coupled receptors and subsequent intracellular signaling events, they enhance leukocyte accumulation, phagocyte capacity for microbial ingestion and killing, and generation of other proinflammatory mediators. Interestingly, a variety of acquired states of immunodeficiency, such as HIV infection and malnutrition, are characterized by a relative deficiency of leukotriene synthesis. The data reviewed herein point to leukotrienes as underappreciated yet highly relevant mediators of innate immunity.
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ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.174.2.589