Effect of vimentin on cell migration in collagen-coated microchannels: A mimetic physiological confined environment

• Published in: Biomicrofluidics Vol. 15; no. 3; pp. 034105 - 34111
• Main Authors: Zhou, Zhiru, Cui, Feiyun, Wen, Qi, Susan Zhou, H.
• Format: Journal Article
• Language: English
• Published: United States American Institute of Physics 01.05.2021; AIP Publishing LLC
• Subjects: Cancer; Cell adhesion; Cell adhesion & migration; Collagen; Confined spaces; Confinement; Fibroblasts; In vivo methods and tests; Leading edges; Microchannels; Microfluidic devices; Morphology; Physiological effects; Physiology; Regular

Cancer cell migration through tissue pores and tracks into the bloodstream is a critical biological step for cancer metastasis. Although in vivo studies have shown that expression of vimentin can induce invasive cell lines, its role in cell cytoskeleton reorganization and cell motility under in vitr...