Pathogenic roles of microvesicles in diabetic retinopathy

Diabetic retinopathy （DR） is a common complication of diabetes and has been recognized as the leading cause of blindness in adults. Several interrelated molecular pathways are involved in the development of DR. Microvesicles （MVs） are cell membrane vesicles, which carry many biologic molecules, such...

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Published inActa pharmacologica Sinica Vol. 39; no. 1; pp. 1 - 11
Main Authors Zhang, Wei, Chen, Song, Liu, Ming-Lin
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.01.2018
Nature Publishing Group
Subjects
Angiogenesis
Animals
Biomedical and Life Sciences
Biomedicine
Blindness
Cell signaling
Cell-Derived Microparticles - metabolism
Cell-Derived Microparticles - physiology
Coagulation
Diabetes
Diabetes mellitus
Diabetic retinopathy
Diabetic Retinopathy - physiopathology
Diabetic Retinopathy - therapy
Endothelial Cells - pathology
Endothelial Cells - physiology
Endothelium, Vascular - pathology
Humans
Immunology
Inflammation - physiopathology
Inflammation - therapy
Internal Medicine
Lipids
Medical Microbiology
Membrane vesicles
Metalloendopeptidases - metabolism
MicroRNAs - metabolism
Microvasculature
Microvessels - pathology
miRNA
Neovascularization, Pathologic - pathology
Neovascularization, Pathologic - therapy
Pharmacology/Toxicology
Retinopathy
Review
Stem cells
Stem Cells - metabolism
Transcription factors
Tumors
Vaccine
stem cells
vascular inflammation
microvesicles
miRNAs
diabetic retinopathy
Online AccessGet full text
ISSN1671-4083
1745-7254
1745-7254
DOI10.1038/aps.2017.77

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Abstract Diabetic retinopathy （DR） is a common complication of diabetes and has been recognized as the leading cause of blindness in adults. Several interrelated molecular pathways are involved in the development of DR. Microvesicles （MVs） are cell membrane vesicles, which carry many biologic molecules, such as mRNAs, microRNAs, transcription factors, membrane lipids, membrane receptors, and other proteins. They may be involved in intercellular communication that can promote inflammation, angiogenesis, and coagulation. Recent studies have indicated that changes in the number and composition of MVs may reflect the pathologic conditions of DR. At present, MVs are well recognized as being involved in the pathophysiological conditions of tumors and cardio-metabolic diseases. However, the roles of MVs in DR have yet to be investigated. In this review, we provide an overview of DR-induced microvascular injury that is caused by MVs derived from endothelial and circulating cells, and discuss the possible mechanisms by which MVs can lead to endothelial dysfunction, coagulation and inflammation. In addition, the protective effects of preconditioned MVs and stem cell-derived MVs are also described. Understanding the involvement of MVs in the pathophysiological conditions of DR may provide insight into the disease mechanisms and may suggest novel therapeuticstrategies for DR in the future.
AbstractList Diabetic retinopathy (DR) is a common complication of diabetes and has been recognized as the leading cause of blindness in adults. Several interrelated molecular pathways are involved in the development of DR. Microvesicles (MVs) are cell membrane vesicles, which carry many biologic molecules, such as mRNAs, microRNAs, transcription factors, membrane lipids, membrane receptors, and other proteins. They may be involved in intercellular communication that can promote inflammation, angiogenesis, and coagulation. Recent studies have indicated that changes in the number and composition of MVs may reflect the pathologic conditions of DR. At present, MVs are well recognized as being involved in the pathophysiological conditions of tumors and cardio-metabolic diseases. However, the roles of MVs in DR have yet to be investigated. In this review, we provide an overview of DR-induced microvascular injury that is caused by MVs derived from endothelial and circulating cells, and discuss the possible mechanisms by which MVs can lead to endothelial dysfunction, coagulation and inflammation. In addition, the protective effects of preconditioned MVs and stem cell-derived MVs are also described . Understanding the involvement of MVs in the pathophysiological conditions of DR may provide insight into the disease mechanisms and may suggest novel therapeutic strategies for DR in the future.
Diabetic retinopathy （DR） is a common complication of diabetes and has been recognized as the leading cause of blindness in adults. Several interrelated molecular pathways are involved in the development of DR. Microvesicles （MVs） are cell membrane vesicles, which carry many biologic molecules, such as mRNAs, microRNAs, transcription factors, membrane lipids, membrane receptors, and other proteins. They may be involved in intercellular communication that can promote inflammation, angiogenesis, and coagulation. Recent studies have indicated that changes in the number and composition of MVs may reflect the pathologic conditions of DR. At present, MVs are well recognized as being involved in the pathophysiological conditions of tumors and cardio-metabolic diseases. However, the roles of MVs in DR have yet to be investigated. In this review, we provide an overview of DR-induced microvascular injury that is caused by MVs derived from endothelial and circulating cells, and discuss the possible mechanisms by which MVs can lead to endothelial dysfunction, coagulation and inflammation. In addition, the protective effects of preconditioned MVs and stem cell-derived MVs are also described. Understanding the involvement of MVs in the pathophysiological conditions of DR may provide insight into the disease mechanisms and may suggest novel therapeuticstrategies for DR in the future.
Diabetic retinopathy (DR) is a common complication of diabetes and has been recognized as the leading cause of blindness in adults. Several interrelated molecular pathways are involved in the development of DR. Microvesicles (MVs) are cell membrane vesicles, which carry many biologic molecules, such as mRNAs, microRNAs, transcription factors, membrane lipids, membrane receptors, and other proteins. They may be involved in intercellular communication that can promote inflammation, angiogenesis, and coagulation. Recent studies have indicated that changes in the number and composition of MVs may reflect the pathologic conditions of DR. At present, MVs are well recognized as being involved in the pathophysiological conditions of tumors and cardio-metabolic diseases. However, the roles of MVs in DR have yet to be investigated. In this review, we provide an overview of DR-induced microvascular injury that is caused by MVs derived from endothelial and circulating cells, and discuss the possible mechanisms by which MVs can lead to endothelial dysfunction, coagulation and inflammation. In addition, the protective effects of preconditioned MVs and stem cell-derived MVs are also described . Understanding the involvement of MVs in the pathophysiological conditions of DR may provide insight into the disease mechanisms and may suggest novel therapeutic strategies for DR in the future.Diabetic retinopathy (DR) is a common complication of diabetes and has been recognized as the leading cause of blindness in adults. Several interrelated molecular pathways are involved in the development of DR. Microvesicles (MVs) are cell membrane vesicles, which carry many biologic molecules, such as mRNAs, microRNAs, transcription factors, membrane lipids, membrane receptors, and other proteins. They may be involved in intercellular communication that can promote inflammation, angiogenesis, and coagulation. Recent studies have indicated that changes in the number and composition of MVs may reflect the pathologic conditions of DR. At present, MVs are well recognized as being involved in the pathophysiological conditions of tumors and cardio-metabolic diseases. However, the roles of MVs in DR have yet to be investigated. In this review, we provide an overview of DR-induced microvascular injury that is caused by MVs derived from endothelial and circulating cells, and discuss the possible mechanisms by which MVs can lead to endothelial dysfunction, coagulation and inflammation. In addition, the protective effects of preconditioned MVs and stem cell-derived MVs are also described . Understanding the involvement of MVs in the pathophysiological conditions of DR may provide insight into the disease mechanisms and may suggest novel therapeutic strategies for DR in the future.
Author Wei ZHANG;Song CHEN;Ming-Lin LIU
AuthorAffiliation Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology Tianjin Medical University, Tianjin 300020, China;Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;Corporal Michael J Crescenz VA Medical Center （Philadelphia）, Philadelphia, PA 19104, USA;Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
Author_xml – sequence: 1
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  fullname: Zhang, Wei
  organization: Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology Tianjin Medical University
– sequence: 2
  givenname: Song
  surname: Chen
  fullname: Chen, Song
  email: chensong9999@126.com
  organization: Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology Tianjin Medical University
– sequence: 3
  givenname: Ming-Lin
  surname: Liu
  fullname: Liu, Ming-Lin
  email: lium1@mail.med.upenn.edu
  organization: Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Corporal Michael J Crescenz VA Medical Center (Philadelphia), Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, Temple University School of Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28713160$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords stem cells
vascular inflammation
microvesicles
miRNAs
diabetic retinopathy
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c473t-21211bafd36f24429869b45ebe3d2db308de7e926e2cdcea347daa07e88ce2a3
Notes Diabetic retinopathy （DR） is a common complication of diabetes and has been recognized as the leading cause of blindness in adults. Several interrelated molecular pathways are involved in the development of DR. Microvesicles （MVs） are cell membrane vesicles, which carry many biologic molecules, such as mRNAs, microRNAs, transcription factors, membrane lipids, membrane receptors, and other proteins. They may be involved in intercellular communication that can promote inflammation, angiogenesis, and coagulation. Recent studies have indicated that changes in the number and composition of MVs may reflect the pathologic conditions of DR. At present, MVs are well recognized as being involved in the pathophysiological conditions of tumors and cardio-metabolic diseases. However, the roles of MVs in DR have yet to be investigated. In this review, we provide an overview of DR-induced microvascular injury that is caused by MVs derived from endothelial and circulating cells, and discuss the possible mechanisms by which MVs can lead to endothelial dysfunction, coagulation and inflammation. In addition, the protective effects of preconditioned MVs and stem cell-derived MVs are also described. Understanding the involvement of MVs in the pathophysiological conditions of DR may provide insight into the disease mechanisms and may suggest novel therapeuticstrategies for DR in the future.
microvesicles; diabetic retinopathy; stem cells; vascular inflammation; miRNAs
31-1347/R
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SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
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OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/aps.2017.77
PMID 28713160
PQID 1984770452
PQPubID 28815
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PublicationCentury 2000
PublicationDate 2018-01-01
PublicationDateYYYYMMDD 2018-01-01
PublicationDate_xml – month: 01
  year: 2018
  text: 2018-01-01
  day: 01
PublicationDecade 2010
PublicationPlace London
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– name: Shanghai
PublicationTitle Acta pharmacologica Sinica
PublicationTitleAbbrev Acta Pharmacol Sin
PublicationTitleAlternate Acta Pharmacologica Sinica
PublicationYear 2018
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
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Snippet Diabetic retinopathy （DR） is a common complication of diabetes and has been recognized as the leading cause of blindness in adults. Several interrelated...
Diabetic retinopathy (DR) is a common complication of diabetes and has been recognized as the leading cause of blindness in adults. Several interrelated...
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SubjectTerms Angiogenesis
Animals
Biomedical and Life Sciences
Biomedicine
Blindness
Cell signaling
Cell-Derived Microparticles - metabolism
Cell-Derived Microparticles - physiology
Coagulation
Diabetes
Diabetes mellitus
Diabetic retinopathy
Diabetic Retinopathy - physiopathology
Diabetic Retinopathy - therapy
Endothelial Cells - pathology
Endothelial Cells - physiology
Endothelium, Vascular - pathology
Humans
Immunology
Inflammation - physiopathology
Inflammation - therapy
Internal Medicine
Lipids
Medical Microbiology
Membrane vesicles
Metalloendopeptidases - metabolism
MicroRNAs - metabolism
Microvasculature
Microvessels - pathology
miRNA
Neovascularization, Pathologic - pathology
Neovascularization, Pathologic - therapy
Pharmacology/Toxicology
Retinopathy
Review
Stem cells
Stem Cells - metabolism
Transcription factors
Tumors
Vaccine
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Title Pathogenic roles of microvesicles in diabetic retinopathy
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