Use of Decellularized Porcine Liver for Engineering Humanized Liver Organ

• Published in: The Journal of surgical research Vol. 173; no. 1; pp. e11 - e25
• Main Authors: Barakat, Omar, M.D., F.R.C.S, Abbasi, Shahrzad, M.S, Rodriguez, Gabriela, M.D, Rios, Jessie, Wood, R. Patrick, M.D, Ozaki, Claire, M.D, Holley, Laurie S., M.D, Gauthier, Polly K., M.D
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2012
• Subjects: Animals; bioartificial liver; Cell Proliferation; Cell Survival; Cell Transplantation - methods; Cells, Cultured; Coculture Techniques; end-stage liver disease; Glucose - metabolism; Hepatic Stellate Cells - cytology; Hepatic Stellate Cells - transplantation; hepatocyte transplantation; Hepatocytes - cytology; Hepatocytes - transplantation; Humans; Lactates - metabolism; Liver - cytology; Liver - metabolism; Liver Transplantation; Oxygen - metabolism; Pilot Projects; Surgery; Swine; tissue engineering; Tissue Engineering - methods; Transplantation, Heterologous; hepatocyte transplantation; tissue engineering; end-stage liver disease; bioartificial liver; liver transplantation

Background New bioartificial liver devices are needed to supplement the limited supply of organ donors available for patients with end-stage liver disease. Here, we report the results of a pilot study aimed at developing a humanized porcine liver by transplanting second trimester human fetal hepatoc...