Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways

• Published in: American journal of obstetrics and gynecology Vol. 226; no. 2; pp. S907 - S927
• Main Authors: Redman, Christopher W.G., Staff, Anne Cathrine, Roberts, James M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2022
• Subjects: Apoptosis; Autophagy; big data; cell stress; Cellular Senescence - physiology; chorionic villous crowding; competing risks; endoplasmic reticulum stress; Extracellular Vesicles - metabolism; Female; fetal death; fetal growth restriction; Fibrin - metabolism; Humans; maternal factors; mitochondria; Necrosis; oxidative stress; placental senescence; Placentation - physiology; Pre-Eclampsia - pathology; Pre-Eclampsia - physiopathology; Pregnancy; pyroptosis; Stress, Physiological; subtypes; term stillbirths; Trophoblasts - physiology; autophagy; maternal factors; mitochondria; apoptosis; fetal death; endoplasmic reticulum stress; subtypes; term stillbirths; pyroptosis; fetal growth restriction; chorionic villous crowding; cell stress; placental senescence; competing risks; big data; oxidative stress

Preeclampsia evolves in 2 stages: a placental problem that generates signals to the mother to cause a range of responses that comprise the second stage (preeclampsia syndrome). The first stage of early-onset preeclampsia is poor placentation, which we here call malplacentation. The spiral arteries a...