Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons

• Published in: Nature neuroscience Vol. 22; no. 2; pp. 243 - 255
• Main Authors: Schafer, Simon T., Paquola, Apua C. M., Stern, Shani, Gosselin, David, Ku, Manching, Pena, Monique, Kuret, Thomas J. M., Liyanage, Marvin, Mansour, Abed AlFatah, Jaeger, Baptiste N., Marchetto, Maria C., Glass, Christopher K., Mertens, Jerome, Gage, Fred H.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.02.2019; Nature Publishing Group
• Subjects: 13; 13/100; 38; 38/39; 38/91; 631/378/1689/1373; 631/378/2571/1696; 631/532/2064/2158; Animal Genetics and Genomics; Autism; Autism Spectrum Disorder - genetics; Autism Spectrum Disorder - pathology; Autism Spectrum Disorder - physiopathology; Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Brain; Care and treatment; Chromatin; Cortex; Developmental stages; Direct conversion; Gene expression; Gene Regulatory Networks; Genes; Humans; Induced Pluripotent Stem Cells - pathology; Inhibitory postsynaptic potentials; Inhibitory Postsynaptic Potentials - physiology; Macrocephaly; Nerve Net - physiopathology; Neural stem cells; Neural Stem Cells - pathology; Neurobiology; Neurons; Neurons - pathology; Neurons - physiology; Neurosciences; Pervasive developmental disorders; Phenotypes; Pluripotency; Priming; Risk factors; Stem cells

Autism spectrum disorder (ASD) is thought to emerge during early cortical development. However, the exact developmental stages and associated molecular networks that prime disease propensity are elusive. To profile early neurodevelopmental alterations in ASD with macrocephaly, we monitored subject-d...