Regulation of insulin gene expression by overlapping DNA-binding elements

• Published in: Biochemical journal Vol. 392; no. Pt 1; pp. 181 - 189
• Main Authors: Nishimura, Wataru, Salameh, Therese, Kondo, Takuma, Sharma, Arun
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd 15.11.2005
• Subjects: Animals; Binding Sites; Cell Line; Enhancer Elements, Genetic - genetics; Gene Expression Regulation - genetics; Insulin - biosynthesis; Insulin - genetics; Maf Transcription Factors, Large - metabolism; Protein Binding; Response Elements - genetics

The transcription factor MafA/RIPE3b1 is an important regulator of insulin gene expression. MafA binds to the insulin enhancer element RIPE3b (C1-A2), now designated as insulin MARE (Maf response element). The insulin MARE element shares an overlapping DNA-binding region with another insulin enhance...