NAD(P)H oxidase-derived reactive oxygen species contribute to age-related impairments of endothelium-dependent dilation in rat soleus feed arteries

• Published in: Journal of applied physiology (1985) Vol. 110; no. 5; pp. 1171 - 1180
• Main Authors: TROTT, Daniel W, SEAWRIGHT, John W, LUTTRELL, Meredith J, WOODMAN, Christopher R
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.05.2011
• Subjects: Aging - physiology; Animals; Arteries - metabolism; Biological and medical sciences; Blood Flow Velocity - physiology; Endothelium, Vascular - physiology; Fundamental and applied biological sciences. Psychology; Hydrogen peroxide; Male; Muscle, Skeletal - blood supply; Muscle, Skeletal - physiology; NADPH Oxidases - metabolism; Oxidation; Oxygen; Proteins; Rats; Rats, Inbred F344; Reactive Oxygen Species - metabolism; Rodents; Vasodilation - physiology; Veins & arteries; Reactive oxygen species; Hydrogen peroxide; Rat; Enzyme; Rodentia; Superoxide dismutase; Artery; endothelium-derived hyperpolarizing factor; Endothelium; NAD; Vertebrata; Mammalia; Blood vessel; Circulatory system; Oxidoreductases; superoxide; Age; catalase

We tested the hypothesis that age-related endothelial dysfunction in rat soleus muscle feed arteries (SFA) is mediated in part by NAD(P)H oxidase-derived reactive oxygen species (ROS). SFA from young (4 mo) and old (24 mo) Fischer 344 rats were isolated and cannulated for examination of vasodilator...