Mutations in the Genes Regulating Methylene Tetrahydrofolate Reductase (MTHFR C→T677) and Cystathione β-Synthase (CBS G→A919, CBS T→c833) Are Not Associated with Myocardial Infarction in African Americans

• Published in: Thrombosis research Vol. 103; no. 2; pp. 109 - 115
• Main Authors: Dilley, Anne, Hooper, W.Craig, El-Jamil, Muhydine, Renshaw, Mary, Wenger, Nanette Kass, Evatt, Bruce L
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 15.07.2001; Elsevier Science
• Subjects: Adult; African Americans; African Continental Ancestry Group - genetics; Amino Acid Substitution; Biological and medical sciences; Cardiology. Vascular system; Case-Control Studies; CBS gene; Comorbidity; Coronary heart disease; Cystathionine beta-Synthase - biosynthesis; Cystathionine beta-Synthase - genetics; DNA Mutational Analysis; Enzyme Induction; Female; Genetic Predisposition to Disease; Genotype; Georgia - epidemiology; Heart; Homocysteine; Humans; Hyperhomocysteinemia - complications; Hyperhomocysteinemia - enzymology; Hyperhomocysteinemia - ethnology; Hyperhomocysteinemia - genetics; Hypertension - epidemiology; Male; Medical sciences; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; MTHFR gene; Mutation, Missense; Myocardial infarction; Myocardial Infarction - enzymology; Myocardial Infarction - ethnology; Myocardial Infarction - etiology; Myocardial Infarction - genetics; Oxidoreductases Acting on CH-NH Group Donors - biosynthesis; Oxidoreductases Acting on CH-NH Group Donors - genetics; Georgia; Myocardial infarction; African Americans; Homocysteine; MTHFR gene; CBS gene; Human; Methylenetetrahydrofolate reductase (NADPH); Infarct; Enzyme; Negroid; Cardiovascular disease; Lyases; Cystathionine β-synthase; Coronary heart disease; Myocardial disease; Genetic determinism; Gene; Risk factor; Race; Myocardium; Oxidoreductases; Mutation; Carbon-oxygen lyases; Hydro-lyases

Moderate hyperhomocysteinemia is a putative risk factor for cardiovascular disease. Molecular studies have demonstrated increased plasma homocysteine levels in the presence of DNA mutations in either the methylenetetrahydrofolate reductase (MTHFR) enzyme found in the remethylation pathway or the enz...