IFN-γ enhances the efficacy of mesenchymal stromal cell-derived exosomes via miR-21 in myocardial infarction rats

• Published in: Stem cell research & therapy Vol. 13; no. 1; pp. 1 - 14
• Main Authors: Zhang, Jian, Lu, Yao, Mao, Yangming, Yu, Yue, Wu, Tianyu, Zhao, Wei, Zhu, Yeqian, Zhao, Pengcheng, Zhang, Fengxiang
• Format: Journal Article
• Language: English
• Published: London BioMed Central 23.07.2022; BMC
• Subjects: Angiogenesis; Antibodies; Apoptosis; BTG2 protein; Cardiomyocytes; Cell culture; Endothelial cells; Exosome; Exosomes; Fibrosis; Gene expression; Gene regulation; Heart attacks; IFN-γ; Laboratory animals; Medical research; Mesenchyme; MicroRNAs; miR-21-5p; miRNA; MSCs; Myocardial infarction; Proteins; Reagents; Reporter gene; Reverse transcription; Signal transduction; Stat1 protein; Stromal cells; Transcription factors; Umbilical vein; γ-Interferon; United States > US; China

Background Mesenchymal stromal cells (MSCs) activated with IFN-γ elicit stronger physical effects. Exosomes (Exos) secreted from MSCs show protective effects against myocardial injury. This study aimed to determine whether Exos derived from IFN-γ-treated MSCs exhibit more potent cardioprotective fun...