Elucidation of the Anticancer Mechanism of Durian Fruit ( Durio zibethinus ) Pulp Extract in Human Leukemia (HL-60) Cancer Cells

• Published in: Nutrients Vol. 15; no. 10; p. 2417
• Main Authors: Abdul Rahman, Mohamad Sitheek, Kanakarajan, Sivakumari, Selvaraj, Rajesh, Kamalanathan, Ashok, Fatima, Sabiha, Abudawood, Manal, Siddiqi, Nikhat J, Alanazi, Humidah, Sharma, Bechan, de Lourdes Pereira, Maria
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.05.2023; MDPI
• Subjects: Acids; anticancer activity; Apoptosis; BAX protein; Bcl-2 protein; Bcl-x protein; Biotechnology; Bombacaceae - genetics; Bombacaceae - metabolism; Cancer; Carbohydrates; Cell cycle; Cell division; Deoxyribonucleic acid; DNA; DNA damage; DNA fragmentation; Durio zibethinus; Fibers; Fruit - metabolism; Fruits; Herbal medicine; HL-60 Cells; Humans; Leukemia; Lipids; Membranes; Methanol; Neoplasms - metabolism; Proteins; S phase; Vitamins; Vitamins - metabolism; United States > US; Germany; India; apoptosis; anticancer activity; cell cycle; Durio zibethinus; DNA fragmentation

Durian ( L.) grows widely in Southeast Asia. The pulp of the durian fruit contains carbohydrates, proteins, lipids, fibers, various vitamins, minerals, and fatty acids. This study was carried out to elucidate the anticancer mechanism of action of the methanolic extract of the fruit of ( ) on human l...