Elucidation of the Anticancer Mechanism of Durian Fruit ( Durio zibethinus ) Pulp Extract in Human Leukemia (HL-60) Cancer Cells

Durian ( L.) grows widely in Southeast Asia. The pulp of the durian fruit contains carbohydrates, proteins, lipids, fibers, various vitamins, minerals, and fatty acids. This study was carried out to elucidate the anticancer mechanism of action of the methanolic extract of the fruit of ( ) on human l...

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Published inNutrients Vol. 15; no. 10; p. 2417
Main Authors Abdul Rahman, Mohamad Sitheek, Kanakarajan, Sivakumari, Selvaraj, Rajesh, Kamalanathan, Ashok, Fatima, Sabiha, Abudawood, Manal, Siddiqi, Nikhat J, Alanazi, Humidah, Sharma, Bechan, de Lourdes Pereira, Maria
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 22.05.2023
MDPI
Subjects
Acids
anticancer activity
Apoptosis
BAX protein
Bcl-2 protein
Bcl-x protein
Biotechnology
Bombacaceae - genetics
Bombacaceae - metabolism
Cancer
Carbohydrates
Cell cycle
Cell division
Deoxyribonucleic acid
DNA
DNA damage
DNA fragmentation
Durio zibethinus
Fibers
Fruit - metabolism
Fruits
Herbal medicine
HL-60 Cells
Humans
Leukemia
Lipids
Membranes
Methanol
Neoplasms - metabolism
Proteins
S phase
Vitamins
Vitamins - metabolism
United States > US
Germany
India
apoptosis
anticancer activity
cell cycle
Durio zibethinus
DNA fragmentation
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Abstract Durian ( L.) grows widely in Southeast Asia. The pulp of the durian fruit contains carbohydrates, proteins, lipids, fibers, various vitamins, minerals, and fatty acids. This study was carried out to elucidate the anticancer mechanism of action of the methanolic extract of the fruit of ( ) on human leukemia (HL-60) cells. The methanolic extract of fruits exhibited its anticancer effect on HL-60 cells by inducing DNA damage and apoptosis. The DNA damage was confirmed by comet and DNA fragmentation assays. The methanolic extract of fruits has been shown to cause cell cycle arrest in HL-60 cells during the S phase and G2/M phase. Additionally, the methanolic extract caused induction of the apoptotic pathway in the HL-60 cell line. This was confirmed by increased expression in pro-apoptotic proteins, viz., Bax protein expression, and a substantial reduction ( < 0.001) in anti-apoptotic proteins, viz., Bcl-2 and Bcl-xL expressions. Therefore, this study confirms that the methanolic extract of exerts its anticancer effects on the HL-60 cell line, causing cell cycle arrest and induction of apoptosis by an intrinsic mechanism.
AbstractList Durian ( L.) grows widely in Southeast Asia. The pulp of the durian fruit contains carbohydrates, proteins, lipids, fibers, various vitamins, minerals, and fatty acids. This study was carried out to elucidate the anticancer mechanism of action of the methanolic extract of the fruit of ( ) on human leukemia (HL-60) cells. The methanolic extract of fruits exhibited its anticancer effect on HL-60 cells by inducing DNA damage and apoptosis. The DNA damage was confirmed by comet and DNA fragmentation assays. The methanolic extract of fruits has been shown to cause cell cycle arrest in HL-60 cells during the S phase and G2/M phase. Additionally, the methanolic extract caused induction of the apoptotic pathway in the HL-60 cell line. This was confirmed by increased expression in pro-apoptotic proteins, viz., Bax protein expression, and a substantial reduction ( < 0.001) in anti-apoptotic proteins, viz., Bcl-2 and Bcl-xL expressions. Therefore, this study confirms that the methanolic extract of exerts its anticancer effects on the HL-60 cell line, causing cell cycle arrest and induction of apoptosis by an intrinsic mechanism.
Durian (Durio zibethinus L.) grows widely in Southeast Asia. The pulp of the durian fruit contains carbohydrates, proteins, lipids, fibers, various vitamins, minerals, and fatty acids. This study was carried out to elucidate the anticancer mechanism of action of the methanolic extract of the fruit of Durio zibethinus (D. zibethinus) on human leukemia (HL-60) cells. The methanolic extract of D. zibethinus fruits exhibited its anticancer effect on HL-60 cells by inducing DNA damage and apoptosis. The DNA damage was confirmed by comet and DNA fragmentation assays. The methanolic extract of D. zibethinus fruits has been shown to cause cell cycle arrest in HL-60 cells during the S phase and G2/M phase. Additionally, the methanolic extract caused induction of the apoptotic pathway in the HL-60 cell line. This was confirmed by increased expression in pro-apoptotic proteins, viz., Bax protein expression, and a substantial reduction (p < 0.001) in anti-apoptotic proteins, viz., Bcl-2 and Bcl-xL expressions. Therefore, this study confirms that the methanolic extract of D. zibethinus exerts its anticancer effects on the HL-60 cell line, causing cell cycle arrest and induction of apoptosis by an intrinsic mechanism.
Durian ( Durio zibethinus L.) grows widely in Southeast Asia. The pulp of the durian fruit contains carbohydrates, proteins, lipids, fibers, various vitamins, minerals, and fatty acids. This study was carried out to elucidate the anticancer mechanism of action of the methanolic extract of the fruit of Durio zibethinus ( D. zibethinus ) on human leukemia (HL-60) cells. The methanolic extract of D. zibethinus fruits exhibited its anticancer effect on HL-60 cells by inducing DNA damage and apoptosis. The DNA damage was confirmed by comet and DNA fragmentation assays. The methanolic extract of D. zibethinus fruits has been shown to cause cell cycle arrest in HL-60 cells during the S phase and G2/M phase. Additionally, the methanolic extract caused induction of the apoptotic pathway in the HL-60 cell line. This was confirmed by increased expression in pro-apoptotic proteins, viz., Bax protein expression, and a substantial reduction ( p < 0.001) in anti-apoptotic proteins, viz., Bcl-2 and Bcl-xL expressions. Therefore, this study confirms that the methanolic extract of D. zibethinus exerts its anticancer effects on the HL-60 cell line, causing cell cycle arrest and induction of apoptosis by an intrinsic mechanism.
Author Sharma, Bechan
Kamalanathan, Ashok
de Lourdes Pereira, Maria
Abudawood, Manal
Alanazi, Humidah
Abdul Rahman, Mohamad Sitheek
Fatima, Sabiha
Kanakarajan, Sivakumari
Selvaraj, Rajesh
Siddiqi, Nikhat J
AuthorAffiliation 3 Department of Biochemistry, College of Science, King Saud University, Riyadh 11495, Saudi Arabia
2 Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia
4 Department of Biochemistry, Faculty of Science, University of Allahabad, Allahabad 211002, India
5 Department of Medical Sciences, CICECO—Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal
1 Department of Zoology, Presidency College, Chennai 600005, India
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CitedBy_id crossref_primary_10_1038_s41598_024_65219_6
crossref_primary_10_47836_mjmhs_19_s9_5
crossref_primary_10_3390_horticulturae10040342
crossref_primary_10_1111_ijfs_16886
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Keywords apoptosis
anticancer activity
cell cycle
Durio zibethinus
DNA fragmentation
Language English
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Snippet Durian ( L.) grows widely in Southeast Asia. The pulp of the durian fruit contains carbohydrates, proteins, lipids, fibers, various vitamins, minerals, and...
Durian (Durio zibethinus L.) grows widely in Southeast Asia. The pulp of the durian fruit contains carbohydrates, proteins, lipids, fibers, various vitamins,...
Durian ( Durio zibethinus L.) grows widely in Southeast Asia. The pulp of the durian fruit contains carbohydrates, proteins, lipids, fibers, various vitamins,...
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StartPage 2417
SubjectTerms Acids
anticancer activity
Apoptosis
BAX protein
Bcl-2 protein
Bcl-x protein
Biotechnology
Bombacaceae - genetics
Bombacaceae - metabolism
Cancer
Carbohydrates
Cell cycle
Cell division
Deoxyribonucleic acid
DNA
DNA damage
DNA fragmentation
Durio zibethinus
Fibers
Fruit - metabolism
Fruits
Herbal medicine
HL-60 Cells
Humans
Leukemia
Lipids
Membranes
Methanol
Neoplasms - metabolism
Proteins
S phase
Vitamins
Vitamins - metabolism
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Title Elucidation of the Anticancer Mechanism of Durian Fruit ( Durio zibethinus ) Pulp Extract in Human Leukemia (HL-60) Cancer Cells
URI https://www.ncbi.nlm.nih.gov/pubmed/37242300
https://www.proquest.com/docview/2819479593/abstract/
https://search.proquest.com/docview/2820019974
https://pubmed.ncbi.nlm.nih.gov/PMC10221080
https://doaj.org/article/9e2d9a3cfe584d4099894bd771fdeff6
Volume 15
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