The future of cytokine combination therapy

The hematopoietic growth factors including colony‐stimulating factors (CSF) and interleukins (IL) have overlapping and pleiotropic effects on proliferation and differentiation of progenitor cells and stem cells. The regulatory signals can influence terminal differentiation and the cell cycle status,...

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Bibliographic Details
Published inCancer Vol. 67; no. S10; pp. 2718 - 2726
Main Author Moore, Malcolm A. S.
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 15.05.1991
Subjects
Anemia - therapy
Animals
Cell Differentiation - drug effects
Cells, Cultured - drug effects
Colony-Stimulating Factors - therapeutic use
Cytokines - therapeutic use
Drug Synergism
Hematopoiesis - physiology
Humans
Interleukins - adverse effects
Interleukins - therapeutic use
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Summary:The hematopoietic growth factors including colony‐stimulating factors (CSF) and interleukins (IL) have overlapping and pleiotropic effects on proliferation and differentiation of progenitor cells and stem cells. The regulatory signals can influence terminal differentiation and the cell cycle status, self‐renewal, and differentiation of early pluripotential stem cells. Synergistic interactions between CSF and IL have been shown, both in vitro and in vivo, to be critical in hematopoietic regulation. The future of clinical trials of cytokines in congenital and acquired myelosuppressed states lies in the selective use of appropriate combinations of these regulatory macromolecules.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19910515)67:10+<2718::AID-CNCR2820671709>3.0.CO;2-3