Interferon Alpha‐2a Reduces Early Erythema After Full‐Thickness Skin Graft in the Pig
BACKGROUND Skin grafting is a commonly performed procedure, but studies of changes in the levels of cytokines after skin grafting have not been reported. OBJECTIVE We examined changes in cytokines and the degree of erythema after skin grafting in pigs in the control group. Interferon alpha (IFN‐α) w...
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Published in | Dermatologic surgery Vol. 35; no. 10; pp. 1514 - 1524 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Malden, USA
Blackwell Publishing Inc
01.10.2009
by the American Society for Dermatologic Surgery, Inc Wiley |
Subjects | |
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Abstract | BACKGROUND
Skin grafting is a commonly performed procedure, but studies of changes in the levels of cytokines after skin grafting have not been reported.
OBJECTIVE
We examined changes in cytokines and the degree of erythema after skin grafting in pigs in the control group. Interferon alpha (IFN‐α) was injected to reduce erythema, and subsequent changes in cytokines and the degree of erythema were examined in the experimental group.
METHODS
Vascular endothelial growth factor (VEGF), thrombospondin‐1 (TSP1), and CD31 were examined using Western blot analysis and immunohistochemistry. The degree of erythema was measured at 2, 4, and 8 weeks using a chromometer.
RESULTS
In the control group, VEGF increased at 2 weeks and decreased at 4 and 8 weeks. TSP1 increased over time. CD31 increased to 4 weeks and decreased at 8 weeks. In the experimental group, VEGF was lower at 2 weeks and higher at 8 weeks than in the control group, TSP1 was higher at 2 weeks and lower at 8 weeks, and CD31 was lower at 4 and 8 weeks. Erythema in the experimental group was lower than that in the control group at 2 and 8 weeks.
CONCLUSION
IFN‐α may be one of the agents that reduces erythema by suppressing excessive revascularization. |
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AbstractList | BACKGROUND
Skin grafting is a commonly performed procedure, but studies of changes in the levels of cytokines after skin grafting have not been reported.
OBJECTIVE
We examined changes in cytokines and the degree of erythema after skin grafting in pigs in the control group. Interferon alpha (IFN‐α) was injected to reduce erythema, and subsequent changes in cytokines and the degree of erythema were examined in the experimental group.
METHODS
Vascular endothelial growth factor (VEGF), thrombospondin‐1 (TSP1), and CD31 were examined using Western blot analysis and immunohistochemistry. The degree of erythema was measured at 2, 4, and 8 weeks using a chromometer.
RESULTS
In the control group, VEGF increased at 2 weeks and decreased at 4 and 8 weeks. TSP1 increased over time. CD31 increased to 4 weeks and decreased at 8 weeks. In the experimental group, VEGF was lower at 2 weeks and higher at 8 weeks than in the control group, TSP1 was higher at 2 weeks and lower at 8 weeks, and CD31 was lower at 4 and 8 weeks. Erythema in the experimental group was lower than that in the control group at 2 and 8 weeks.
CONCLUSION
IFN‐α may be one of the agents that reduces erythema by suppressing excessive revascularization. BACKGROUNDSkin grafting is a commonly performed procedure, but studies of changes in the levels of cytokines after skin grafting have not been reported.OBJECTIVEWe examined changes in cytokines and the degree of erythema after skin grafting in pigs in the control group. Interferon alpha (IFN-alpha) was injected to reduce erythema, and subsequent changes in cytokines and the degree of erythema were examined in the experimental group.METHODSVascular endothelial growth factor (VEGF), thrombospondin-1 (TSP1), and CD31 were examined using Western blot analysis and immunohistochemistry. The degree of erythema was measured at 2, 4, and 8 weeks using a chromometer.RESULTSIn the control group, VEGF increased at 2 weeks and decreased at 4 and 8 weeks. TSP1 increased over time. CD31 increased to 4 weeks and decreased at 8 weeks. In the experimental group, VEGF was lower at 2 weeks and higher at 8 weeks than in the control group, TSP1 was higher at 2 weeks and lower at 8 weeks, and CD31 was lower at 4 and 8 weeks. Erythema in the experimental group was lower than that in the control group at 2 and 8 weeks.CONCLUSIONIFN-alpha may be one of the agents that reduces erythema by suppressing excessive revascularization. Skin grafting is a commonly performed procedure, but studies of changes in the levels of cytokines after skin grafting have not been reported. We examined changes in cytokines and the degree of erythema after skin grafting in pigs in the control group. Interferon alpha (IFN-alpha) was injected to reduce erythema, and subsequent changes in cytokines and the degree of erythema were examined in the experimental group. Vascular endothelial growth factor (VEGF), thrombospondin-1 (TSP1), and CD31 were examined using Western blot analysis and immunohistochemistry. The degree of erythema was measured at 2, 4, and 8 weeks using a chromometer. In the control group, VEGF increased at 2 weeks and decreased at 4 and 8 weeks. TSP1 increased over time. CD31 increased to 4 weeks and decreased at 8 weeks. In the experimental group, VEGF was lower at 2 weeks and higher at 8 weeks than in the control group, TSP1 was higher at 2 weeks and lower at 8 weeks, and CD31 was lower at 4 and 8 weeks. Erythema in the experimental group was lower than that in the control group at 2 and 8 weeks. IFN-alpha may be one of the agents that reduces erythema by suppressing excessive revascularization. BACKGROUNDSkin grafting is a commonly performed procedure, but studies of changes in the levels of cytokines after skin grafting have not been reported.OBJECTIVEWe examined changes in cytokines and the degree of erythema after skin grafting in pigs in the control group. Interferon alpha (IFN- alpha ) was injected to reduce erythema, and subsequent changes in cytokines and the degree of erythema were examined in the experimental group.METHODSVascular endothelial growth factor (VEGF), thrombospondin-1 (TSP1), and CD31 were examined using Western blot analysis and immunohistochemistry. The degree of erythema was measured at 2, 4, and 8 weeks using a chromometer.RESULTSIn the control group, VEGF increased at 2 weeks and decreased at 4 and 8 weeks. TSP1 increased over time. CD31 increased to 4 weeks and decreased at 8 weeks. In the experimental group, VEGF was lower at 2 weeks and higher at 8 weeks than in the control group, TSP1 was higher at 2 weeks and lower at 8 weeks, and CD31 was lower at 4 and 8 weeks. Erythema in the experimental group was lower than that in the control group at 2 and 8 weeks.CONCLUSIONIFN- alpha may be one of the agents that reduces erythema by suppressing excessive revascularization.The authors have indicated no significant interest with commercial supporters. BACKGROUNDSkin grafting is a commonly performed procedure, but studies of changes in the levels of cytokines after skin grafting have not been reported. OBJECTIVEWe examined changes in cytokines and the degree of erythema after skin grafting in pigs in the control group. Interferon alpha (IFN-α) was injected to reduce erythema, and subsequent changes in cytokines and the degree of erythema were examined in the experimental group. METHODSVascular endothelial growth factor (VEGF), thrombospondin-1 (TSP1), and CD31 were examined using Western blot analysis and immunohistochemistry. The degree of erythema was measured at 2, 4, and 8 weeks using a chromometer. RESULTSIn the control group, VEGF increased at 2 weeks and decreased at 4 and 8 weeks. TSP1 increased over time. CD31 increased to 4 weeks and decreased at 8 weeks. In the experimental group, VEGF was lower at 2 weeks and higher at 8 weeks than in the control group, TSP1 was higher at 2 weeks and lower at 8 weeks, and CD31 was lower at 4 and 8 weeks. Erythema in the experimental group was lower than that in the control group at 2 and 8 weeks. CONCLUSIONIFN-α may be one of the agents that reduces erythema by suppressing excessive revascularization. |
Author | CHO, HYUN MI ROH, GU SEOB KIM, JUN SIK SON, DAEGU HWANG, O. HYUN PARK, JUNGBIN KIM, NAM GYUN LEE, KYUNG SUK HAN, KIHWAN CHOI, TAE HYUN KIM, JUN HYUNG KIM, WON HEE KIM, SANG‐HYON |
AuthorAffiliation | Daegu Science High School, Daegu, Republic of Korea Department of Plastic and Reconstructive Surgery and Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Republic of Korea Department of Reconstructive Plastic Surgery, Seoul National University Hospital, Seoul, Republic of Korea Department of Plastic and Reconstructive Surgery, Changwon Fatima Hospital, Changwon, Republic of Korea Department of Anatomy, Institute of Health Sciences, College of Medicine and Hospital, Gyeongsang National University, Jinju, Republic of Korea |
AuthorAffiliation_xml | – name: Department of Anatomy, Institute of Health Sciences, College of Medicine and Hospital, Gyeongsang National University, Jinju, Republic of Korea – name: Daegu Science High School, Daegu, Republic of Korea – name: Department of Plastic and Reconstructive Surgery, Changwon Fatima Hospital, Changwon, Republic of Korea – name: Department of Plastic and Reconstructive Surgery and – name: Department of Reconstructive Plastic Surgery, Seoul National University Hospital, Seoul, Republic of Korea – name: Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Republic of Korea |
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Keywords | Antineoplastic agent Skin disease Dermatology Pig Vertebrata Mammalia Interferon alpha 2a Treatment Animal Surgery Graft Early Skin Artiodactyla Erythema Ungulata |
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Skin grafting is a commonly performed procedure, but studies of changes in the levels of cytokines after skin grafting have not been reported.... BACKGROUNDSkin grafting is a commonly performed procedure, but studies of changes in the levels of cytokines after skin grafting have not been reported.... Skin grafting is a commonly performed procedure, but studies of changes in the levels of cytokines after skin grafting have not been reported. We examined... BACKGROUNDSkin grafting is a commonly performed procedure, but studies of changes in the levels of cytokines after skin grafting have not been... |
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SubjectTerms | Angiogenesis Inhibitors - administration & dosage Animals Biological and medical sciences Cytokines - analysis Dermatology Erythema - etiology Erythema - prevention & control Interferon-alpha - administration & dosage Medical sciences Models, Animal Neovascularization, Physiologic Recombinant Proteins Skin - chemistry Skin involvement in other diseases. Miscellaneous. General aspects Skin plastic surgery Skin Transplantation - adverse effects Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Swine |
Title | Interferon Alpha‐2a Reduces Early Erythema After Full‐Thickness Skin Graft in the Pig |
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