Anti‐platelet therapy: ADP receptor antagonists

• Published in: British journal of clinical pharmacology Vol. 72; no. 4; pp. 647 - 657
• Main Authors: Wijeyeratne, Yanushi Dullewe, Heptinstall, Stan
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2011; Blackwell Science Inc
• Subjects: anti‐platelet; Blood Platelets - drug effects; cangrelor; clopidogrel; Haemostasis Themed Issue; Humans; P2Y12; platelet; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - pharmacology; prasugrel; Purinergic P2Y Receptor Antagonists - pharmacology; Thrombosis - prevention & control; ticagrelor

The P2Y12 receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis. Agents that act as antagonists at this receptor are thus likely to provide effective antithrombotic therapy, provided tha...